Concepedia

Fixed Dose Procedure

Fixed Dose Procedure is a standardized toxicological testing method that systematically assesses acute toxicity by administering fixed dose levels of a substance to determine mortality and observable adverse effects in laboratory animals, differing from traditional LD50 tests by minimizing animal suffering and emphasizing clinical signs over death as an endpoint.

44

Publications

2.2K

Citations

163

Authors

72

Institutions

Publications per year

2017–2026

8

Variants

Fdp

Parents

Publications

44

Acute oral toxicity.

Erik Walum · Environmental Health Perspectives · 1998 · 370 citations · Full text

, , +10

Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance

Earnest Oghenesuvwe Erhirhie, Chibueze Peter Ihekwereme, Emmanuel Emeka Ilodigwe · Interdisciplinary Toxicology · 2018 · 323 citations · Full text

, , +12

Haloperidol plasma levels and clinical response: a therapeutic window relationship

T Van Putten, Stephen R. Marder, Jim Mintz et al. · American Journal of Psychiatry · 1992 · 157 citations

, , +15

The international validation of a fixed-dose procedure as an alternative to the classical LD50 test

M.J. van den Heuvel, David G. Clark, R.J. Fielder et al. · Food and Chemical Toxicology · 1990 · 157 citations

, , +7

Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches

Albert Garcia‐Romeu, Frederick S. Barrett, Theresa M. Carbonaro et al. · Journal of Psychopharmacology · 2021 · 99 citations · Full text

, , +13

1–5 of 44

Authors

163

  1. AW
    Anne Whitehead

    University of Reading, United Kingdom

    5 publications · 119 citations

    5

    h-index

  2. NS
    Nigel Stallard

    University of Warwick, United Kingdom

    4 publications · 71 citations

    4

    h-index

  3. JL
    John Langridge

    University of Southampton, United Kingdom

    2 publications · 46 citations

    2

    h-index

  4. CS
    C S Nyanzi

    University Hospital Southampton NHS Foundation Trust, United Kingdom

    2 publications · 46 citations

    2

    h-index

  5. RM
    Ramakrishnan Mani

    University of Otago, New Zealand

    2 publications · 46 citations

    2

    h-index

1–5 of 163

Institutions

72

  1. University of Reading

    Reading, United Kingdom

    5 h-index

    10 publications

    238 citations

  2. University Hospital Southampton NHS Foundation Trust

    Southampton, United Kingdom

    2 h-index

    5 publications

    108 citations

  3. Health and Safety Executive

    Bootle, United Kingdom

    2 h-index

    2 publications

    173 citations

  4. Children's Medical Center

    Dallas, United States

    1 h-index

    1 publications

    13 citations

  5. Federal Institute for Health Protection of Consumers and Veterinary Medicine

    Berlin, Germany

    1 h-index

    1 publications

    28 citations

  6. Östersunds Hospital

    Östersund, Sweden

    1 h-index

    2 publications

    40 citations

  7. University Hospital of Bern

    Bern, Switzerland

    1 h-index

    3 publications

    42 citations

  8. Hôpital Fernand-Widal

    Paris, France

    1 h-index

    2 publications

    138 citations

1–8 of 72

Venues

  1. Food and Chemical Toxicology

    3 publications · 228 citations

    3

    h-index

  2. Human & Experimental Toxicology

    3 publications · 54 citations

    3

    h-index

  3. Psychological Medicine

    2 publications · 47 citations

    2

    h-index

  4. Clinical Rehabilitation

    2 publications · 46 citations

    2

    h-index

  5. Human Reproduction

    1 publications · 14 citations

    1

    h-index

1–5