Fibrogenesis is the biological process involving the formation of fibrous connective tissue, characterized by the synthesis and deposition of extracellular matrix components, particularly collagen, by activated mesenchymal cells. As an academic concept and research field, it investigates the intricate cellular, molecular, and signaling pathways that regulate this process in both physiological contexts, such as wound healing, and pathological states, including chronic diseases where excessive matrix accumulation leads to fibrosis, tissue stiffening, and organ dysfunction, making it a critical area for understanding disease progression and developing therapeutic interventions.