Concepedia

Feedback Activation

Feedback Activation is a regulatory mechanism in signaling pathways whereby the output of a signaling process directly enhances or amplifies the activity of upstream components, distinguishing it from feedforward or independent modulation by establishing a self-reinforcing loop that increases signal sensitivity, gain, or bistability.

107

Publications

10.4K

Citations

794

Authors

282

Institutions

Publications per year

2017–2026

36

Parents

Publications

107

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Anirudh Prahallad, Chong Sun, Sidong Huang et al. · Nature · 2012 · 2.1K citations · Full text

, , +14

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

Xiaolin Wan, B Harkavy, Patrick J. Grohar et al. · Oncogene · 2006 · 747 citations

, , +12

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

Ho-June Lee, Guanglei Zhuang, Yi Cao et al. · Cancer Cell · 2014 · 562 citations · Full text

, , +16

Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS

S.M. Margarit, Holger Sondermann, Brian E. Hall et al. · Cell · 2003 · 483 citations · Full text

, , +15

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

Vincent Ellis, Michael Scully, V. V. Kakkar · Journal of Biological Chemistry · 1989 · 336 citations · Full text

, , +10

1–5 of 107

Authors

794

  1. RB
    René Bernards

    The Netherlands Cancer Institute, Netherlands

    4 publications · 2.1K citations

    4

    h-index

  2. JJ
    Jolyon Jesty

    Stony Brook University, United States

    3 publications · 132 citations

    3

    h-index

  3. YA
    Yuta Adachi

    Kanazawa University, Japan

    2 publications · 248 citations

    2

    h-index

  4. US
    Udo Schumacher

    Universität Hamburg, Germany

    2 publications · 208 citations

    2

    h-index

  5. SJ
    Stephen J. Lupker

    Western University, Canada

    2 publications · 79 citations

    2

    h-index

1–5 of 794

Institutions

282

  1. Stony Brook University

    Stony Brook, United States

    4 h-index

    6 publications

    1.6K citations

  2. State University of New York

    Albany, United States

    4 h-index

    8 publications

    1.7K citations

  3. The Netherlands Cancer Institute

    Amsterdam, The Netherlands

    4 h-index

    19 publications

    10.6K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    4 h-index

    14 publications

    2.2K citations

  5. Massachusetts General Hospital

    Boston, United States

    4 h-index

    36 publications

    3.2K citations

  6. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    14 publications

    2K citations

  7. Center for Cancer Research

    Bethesda, United States

    3 h-index

    19 publications

    4.8K citations

  8. Cornell University

    Ithaca, United States

    3 h-index

    4 publications

    565 citations

1–8 of 282

Venues

  1. Oncotarget

    10 publications · 374 citations

    10

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 328 citations

    4

    h-index

  3. Cancer Cell

    4 publications · 1K citations

    4

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 485 citations

    3

    h-index

  5. Oncogene

    3 publications · 872 citations

    3

    h-index

1–5