Concepedia

Fc Region Structure

Fc Region Structure is the constant structural domain of an antibody molecule that mediates effector functions and determines the antibody's class, distinguishing it from the antigen-binding fragment by its conserved sequence and ability to interact with cell surface receptors and complement proteins.

373

Publications

22.7K

Citations

1.8K

Authors

501

Institutions

Publications per year

2017–2026

58

Variants

Fc Domain Structure

Parents

Publications

373

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

Andrew M. Goetze, Diana Liu, Zhongqi Zhang et al. · Glycobiology · 2011 · 470 citations

, , +17

Refined Structure of an Intact IgG2a Monoclonal Antibody<sup>,</sup>

Lisa J. Harris, Steven B. Larson, Karl W. Hasel et al. · Biochemistry · 1997 · 450 citations

, , +16

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels

Carlos Vaccaro, Jinchun Zhou, Raimund J. Ober et al. · Nature Biotechnology · 2005 · 399 citations

, , +16

Three-dimensional structure of an intact human immunoglobulin.

Enid W. Silverton, Manuel A. Navia, D.R. Davies · Proceedings of the National Academy of Sciences · 1977 · 375 citations · Full text

, , +17

Structure of the Fc fragment of human IgE bound to its high-affinity receptor FcεRIα

Scott C. Garman, Beth A. Wurzburg, Svetlana S. Tarchevskaya et al. · Nature · 2000 · 351 citations

, , +15

1–5 of 373

Authors

1.8K

  1. BJ
    Brian J. Sutton

    King's College London, United Kingdom

    10 publications · 393 citations

    10

    h-index

  2. PJ
    Pamela J. Björkman

    California Institute of Technology, United States

    10 publications · 892 citations

    10

    h-index

  3. PM
    P. Mark Hogarth

    The University of Melbourne, Australia

    8 publications · 684 citations

    8

    h-index

  4. RJ
    Richard J. Pleass

    University of Nottingham, United Kingdom

    8 publications · 390 citations

    8

    h-index

  5. KK
    Koichi Kato

    Nagoya City University, Japan

    7 publications · 781 citations

    7

    h-index

1–5 of 1.8K

Institutions

501

  1. California Institute of Technology

    Pasadena, United States

    10 h-index

    30 publications

    2.3K citations

  2. King's College London

    London, United Kingdom

    9 h-index

    54 publications

    3.4K citations

  3. University of Oxford

    Oxford, United Kingdom

    9 h-index

    30 publications

    914 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    21 publications

    1.5K citations

  5. University College London

    London, United Kingdom

    7 h-index

    22 publications

    1K citations

  6. National Institutes of Health

    Bethesda, United States

    7 h-index

    28 publications

    2.2K citations

  7. University of Birmingham

    Birmingham, United Kingdom

    7 h-index

    16 publications

    613 citations

  8. Inserm

    Paris, France

    7 h-index

    27 publications

    1.6K citations

1–8 of 501

Venues

  1. The Journal of Immunology

    JI · 39 publications · 2.1K citations

    28

    h-index

  2. Journal of Biological Chemistry

    JBC · 22 publications · 2K citations

    21

    h-index

  3. PubMed

    Repository · 27 publications · 1K citations

    18

    h-index

  4. Molecular Immunology

    19 publications · 809 citations

    17

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 1.6K citations

    15

    h-index

1–5