Concepedia

Fab Library Construction

Fab Library Construction is a methodological approach in antibody engineering that involves the creation of a diverse repertoire of Fab fragment genes through the systematic cloning and assembly of variable heavy and light chain gene segments into a phage or yeast display vector for the purpose of selecting antigen-specific antibodies.

129

Publications

10K

Citations

678

Authors

203

Institutions

Publications per year

2017–2026

16

Parents

Publications

129

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

Carlos F. Barbas, Angray S. Kang, Richard A. Lerner et al. · Proceedings of the National Academy of Sciences · 1991 · 1.2K citations

, , +17

Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains

Hennie R. Hoogenboom, Andrew D. Griffiths, Kevin S. Johnson et al. · Nucleic Acids Research · 1991 · 1K citations · Full text

, , +17

Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda

William D. Huse, Lakshmi Sastry, Sheila A. Iverson et al. · Science · 1989 · 805 citations

, , +17

A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies

Hans J. de Haard, Nicole van Neer, Anneke W. Reurs et al. · Journal of Biological Chemistry · 1999 · 533 citations · Full text

, , +17

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

Angray S. Kang, Carlos F. Barbas, Kim D. Janda et al. · Proceedings of the National Academy of Sciences · 1991 · 414 citations

, , +17

1–5 of 129

Authors

678

  1. DR
    Dennis R. Burton

    Scripps Research Institute, United States

    11 publications · 1.6K citations

    11

    h-index

  2. CF
    Carlos F. Barbas

    Scripps Research Institute, United States

    9 publications · 2.5K citations

    9

    h-index

  3. RA
    Richard A. Lerner

    Scripps Research Institute, United States

    5 publications · 2.9K citations

    5

    h-index

  4. AS
    Angray S. Kang

    Scripps Research Institute, United States

    4 publications · 2.7K citations

    4

    h-index

  5. DL
    Don L. Siegel

    University of Pennsylvania, United States

    4 publications · 182 citations

    4

    h-index

1–5 of 678

Institutions

203

  1. Scripps Research Institute

    San Diego, United States

    16 h-index

    59 publications

    17.3K citations

  2. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    11 publications

    579 citations

  3. University of Liège

    Liège, Belgium

    5 h-index

    11 publications

    571 citations

  4. University of Sheffield

    Sheffield, United Kingdom

    4 h-index

    10 publications

    2.1K citations

  5. National Institutes of Health

    Bethesda, United States

    4 h-index

    8 publications

    313 citations

  6. Lund University

    Lund, Sweden

    3 h-index

    6 publications

    176 citations

  7. Van Andel Institute

    Grand Rapids, United States

    3 h-index

    18 publications

    326 citations

  8. Schools of Visual Arts, The Royal Danish Academy of Fine Arts

    Copenhagen, Denmark

    3 h-index

    15 publications

    961 citations

1–8 of 203

Venues

  1. Journal of Immunological Methods

    11 publications · 480 citations

    11

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 2.3K citations

    6

    h-index

  3. Journal of Molecular Biology

    JMB · 6 publications · 598 citations

    6

    h-index

  4. Methods in molecular biology

    Book series · 5 publications · 106 citations

    5

    h-index

  5. PubMed

    Repository · 4 publications · 144 citations

    4

    h-index

1–5