Concepedia

Extracellular Matrix Breakdown

Extracellular Matrix Breakdown is a pathological process characterized by the enzymatic degradation of structural and non-structural macromolecules within the extracellular matrix, primarily mediated by matrix metalloproteinases and aggrecanases, leading to the disruption of tissue architecture and function, particularly in cartilage.

311

Publications

25.2K

Citations

1.7K

Authors

590

Institutions

Publications per year

2017–2026

60

Variants

Ecm Degradation

Parents

Publications

311

Activation mechanisms of matrix metalloproteinases.

Hideaki Nagase · PubMed · 1997 · 1.1K citations

, , +15

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

Ivan E. Collier, S M Wilhelm, Arthur Z. Eisen et al. · Journal of Biological Chemistry · 1988 · 1K citations · Full text

, , +15

Resolution of Lung Inflammation by CD44

Priit Teder, R. William Vandivier, Dianhua Jiang et al. · Science · 2002 · 678 citations

, , +17

Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase

Efrat Kessler, Kazuhiko Takahara, Luba Biniaminov et al. · Science · 1996 · 531 citations

, , +17

TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

Masahide Kashiwagi, Micky D. Tortorella, Hideaki Nagase et al. · Journal of Biological Chemistry · 2001 · 507 citations · Full text

, , +17

1–5 of 311

Authors

1.7K

  1. MD
    Micky D. Tortorella

    Guangzhou Institutes of Biomedicine and Health, China

    7 publications · 1.6K citations

    7

    h-index

  2. GM
    Gillian Murphy

    University of East Anglia, United Kingdom

    7 publications · 923 citations

    7

    h-index

  3. AF
    Amanda Fosang

    Royal Children's Hospital, Australia

    6 publications · 706 citations

    6

    h-index

  4. HN
    Hideaki Nagase

    University of Kansas Medical Center, United States

    6 publications · 2.5K citations

    6

    h-index

  5. EC
    Elizabeth C. Arner

    Wilmington University, United States

    6 publications · 1.1K citations

    6

    h-index

1–5 of 1.7K

Institutions

590

  1. Imperial College London

    London, United Kingdom

    7 h-index

    18 publications

    1.2K citations

  2. Inserm

    Paris, France

    6 h-index

    25 publications

    979 citations

  3. University of Manchester

    Manchester, United Kingdom

    6 h-index

    23 publications

    2.7K citations

  4. McGill University

    Montreal, Canada

    5 h-index

    14 publications

    793 citations

  5. University of Sheffield

    Sheffield, United Kingdom

    5 h-index

    17 publications

    707 citations

  6. Tissue Genetics (United States)

    Aurora, United States

    5 h-index

    10 publications

    560 citations

  7. Washington University in St. Louis

    St Louis, United States

    5 h-index

    22 publications

    11.7K citations

  8. Lund University

    Lund, Sweden

    5 h-index

    15 publications

    834 citations

1–8 of 590

Venues

  1. Journal of Biological Chemistry

    JBC · 25 publications · 4.9K citations

    24

    h-index

  2. PubMed

    Repository · 21 publications · 1.9K citations

    16

    h-index

  3. Biochemical Journal

    BJ · 10 publications · 721 citations

    10

    h-index

  4. American Journal of Respiratory and Critical Care Medicine

    AJRCCM · 6 publications · 744 citations

    6

    h-index

  5. 6

    h-index

1–5