Concepedia

Exosite Recognition

Exosite Recognition is a biochemical mechanism whereby an enzyme selectively binds to a substrate through a secondary binding site distinct from the active site, thereby enhancing substrate specificity and catalytic efficiency.

50

Publications

2.6K

Citations

222

Authors

74

Institutions

Publications per year

2017–2026

1

Parents

Publications

50

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

Szymon W. Manka, Federico Carafoli, Robert Visse et al. · Proceedings of the National Academy of Sciences · 2012 · 222 citations · Full text

, , +17

The interaction of thrombin with fibrinogen

Milton T. Stubbs, Hartmut Oschkinat, Irmgard Mayr et al. · European Journal of Biochemistry · 1992 · 215 citations

, , +15

The isomorphous structures of prethrombin2, hirugen–, and PPACK–thrombin: Changes accompanying activation and exosite binding to thrombin

J. Vijayalakshmi, K. Padmanabhan, A. Tulinsky et al. · Protein Science · 1994 · 143 citations

, , +17

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

Wei‐Qiang Gao, Patricia J. Anderson, Elaine M. Majerus et al. · Proceedings of the National Academy of Sciences · 2006 · 116 citations · Full text

, , +17

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

Wei‐Qiang Gao, Patricia J. Anderson, J. Evan Sadler · Blood · 2008 · 103 citations · Full text

, , +7

1–5 of 50

Authors

222

  1. SK
    Sriram Krishnaswamy

    Children's Hospital of Philadelphia, United States

    6 publications · 335 citations

    6

    h-index

  2. PB
    Paul Bock

    Vanderbilt University, United States

    5 publications · 249 citations

    5

    h-index

  3. JE
    J. Evan Sadler

    Howard Hughes Medical Institute, United States

    3 publications · 242 citations

    3

    h-index

  4. WB
    Wolfram Bode

    Max Planck Institute of Biochemistry, Germany

    3 publications · 269 citations

    3

    h-index

  5. PJ
    Patricia J. Anderson

    Chinese University of Hong Kong, Hong Kong SAR China

    3 publications · 247 citations

    3

    h-index

1–5 of 222

Institutions

74

  1. Vanderbilt University

    Nashville, United States

    5 h-index

    15 publications

    677 citations

  2. Scripps Research Institute

    San Diego, United States

    5 h-index

    17 publications

    930 citations

  3. Children's Hospital of Philadelphia

    Philadelphia, United States

    5 h-index

    10 publications

    507 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    8 publications

    740 citations

  5. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    12 publications

    1.6K citations

  6. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    8 publications

    362 citations

  7. Max Planck Institute of Biochemistry

    Martinsried, Germany

    3 h-index

    11 publications

    1.2K citations

  8. Washington University in St. Louis

    St Louis, United States

    3 h-index

    9 publications

    614 citations

1–8 of 74

Venues

  1. Journal of Biological Chemistry

    JBC · 19 publications · 838 citations

    17

    h-index

  2. Biochemistry

    5 publications · 233 citations

    5

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 495 citations

    4

    h-index

  4. Protein Science

    PS · 3 publications · 177 citations

    3

    h-index

  5. PLoS ONE

    3 publications · 102 citations

    3

    h-index

1–5