Concepedia

Ercc1-xpf Function

Ercc1-Xpf Function is a molecular endonuclease activity that belongs to the DNA repair machinery and is specifically characterized by the heterodimeric complex of Ercc1 and Xpf proteins, which cleaves damaged DNA strands 5' to bulky helix-distorting lesions during nucleotide excision repair.

137

Publications

10.7K

Citations

743

Authors

261

Institutions

Publications per year

2017–2026

34

Variants

Ercc1-xpf Endonuclease Activity

Parents

Publications

137

The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

Laura J. Niedernhofer, Hanny Odijk, Magda Budzowska et al. · Molecular and Cellular Biology · 2004 · 488 citations · Full text

, , +17

Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy.

Meenakshi Dabholkar, Justine Vionnet, Jin‐Tai Yu et al. · Journal of Clinical Investigation · 1994 · 446 citations · Full text

, , +16

Polymorphisms of DNA repair genes and risk of non-small cell lung cancer

Shanbeh Zienolddiny, Daniele Campa, Helge Lind et al. · Carcinogenesis · 2005 · 409 citations · Full text

, , +16

Action of DNA Repair Endonuclease ERCC1/XPF in Living Cells

Adriaan B. Houtsmuller, Suzanne Rademakers, Alex L. Nigg et al. · Science · 1999 · 352 citations

, , +16

Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK

Sofia J. Araújo, Franck Tirode, Frédéric Coin et al. · Genes & Development · 2000 · 333 citations · Full text

, , +17

1–5 of 137

Authors

743

  1. JH
    Jan H.J. Hoeijmakers

    Erasmus University Rotterdam, Netherlands

    13 publications · 1.5K citations

    13

    h-index

  2. LJ
    Laura J. Niedernhofer

    University of Pittsburgh, United States

    9 publications · 986 citations

    9

    h-index

  3. AS
    Aziz Sancar

    University of North Carolina at Chapel Hill, United States

    8 publications · 860 citations

    8

    h-index

  4. WV
    Wim Vermeulen

    Erasmus MC, Netherlands

    7 publications · 757 citations

    7

    h-index

  5. OD
    Orlando D. Schärer

    Stony Brook University, United States

    7 publications · 743 citations

    7

    h-index

1–5 of 743

Institutions

261

  1. Erasmus University Rotterdam

    Rotterdam, The Netherlands

    12 h-index

    47 publications

    6.2K citations

  2. Erasmus MC

    Rotterdam, The Netherlands

    12 h-index

    50 publications

    4.6K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    10 h-index

    30 publications

    3.5K citations

  4. UPMC Hillman Cancer Center

    Pittsburgh, United States

    8 h-index

    21 publications

    2.7K citations

  5. Cancer Research UK

    London, United Kingdom

    8 h-index

    21 publications

    1.7K citations

  6. University of Pittsburgh

    Pittsburgh, United States

    7 h-index

    35 publications

    4.7K citations

  7. Western General Hospital

    Edinburgh, United Kingdom

    6 h-index

    13 publications

    651 citations

  8. University of Alberta

    Edmonton, Canada

    6 h-index

    59 publications

    2K citations

1–8 of 261

Venues

  1. Journal of Biological Chemistry

    JBC · 12 publications · 1.4K citations

    12

    h-index

  2. Nucleic Acids Research

    10 publications · 653 citations

    10

    h-index

  3. The EMBO Journal

    6 publications · 704 citations

    6

    h-index

  4. PubMed

    Repository · 5 publications · 253 citations

    5

    h-index

  5. Molecular and Cellular Biology

    MCB · 5 publications · 999 citations

    5

    h-index

1–5