Concepedia

Epigenomic Clonal Evolution

Epigenomic Clonal Evolution is a theoretical framework that describes the dynamic divergence of epigenomic profiles in cellular lineages over time due to the accumulation of heritable, mitotically stable epigenetic alterations, leading to the emergence of distinct clonal populations within a tissue or tumor.

18

Publications

1.8K

Citations

241

Authors

103

Institutions

Publications per year

2017–2026

10

Parents

Publications

18

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Sheng Li, Francine E. Garrett-Bakelman, Stephen S. Chung et al. · Nature Medicine · 2016 · 401 citations · Full text

, , +16

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

Federico Gaiti, Ronan Chaligné, Hongcang Gu et al. · Nature · 2019 · 271 citations · Full text

, , +16

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

Kimberly D. Siegmund, Paul Marjoram, Yen‐Jung Woo et al. · Proceedings of the National Academy of Sciences · 2009 · 159 citations

, , +17

Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma

Nemanja Rodić, Jared P. Steranka, Alvin P. Makohon-Moore et al. · Nature Medicine · 2015 · 155 citations

, , +14

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

Jin Xu, Kevin A. Nuno, Ulrike Litzenburger et al. · eLife · 2019 · 148 citations · Full text

, , +17

1–5 of 18

Authors

241

  1. CE
    Christopher E. Mason

    Cornell University, United States

    3 publications · 503 citations

    3

    h-index

  2. AM
    Ari Melnick

    Cornell University, United States

    2 publications · 478 citations

    2

    h-index

  3. JX
    Jin Xu

    Stanford University, United States

    2 publications · 163 citations

    2

    h-index

  4. PJ
    Peter J.M. Valk

    Erasmus MC, Netherlands

    2 publications · 540 citations

    2

    h-index

  5. SL
    Sheng Li

    Jackson Laboratory, United States

    2 publications · 478 citations

    2

    h-index

1–5 of 241

Institutions

103

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    4 h-index

    11 publications

    3.2K citations

  2. Cornell University

    Ithaca, United States

    4 h-index

    35 publications

    8.6K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    2 publications

    672 citations

  4. University of Washington

    Seattle, United States

    2 h-index

    14 publications

    644 citations

  5. Johns Hopkins University

    Baltimore, United States

    2 h-index

    16 publications

    2.4K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    6 publications

    223 citations

  7. NYU Langone Health

    New York, United States

    2 h-index

    10 publications

    380 citations

  8. Institute for Stem Cell Biology and Regenerative Medicine

    Bengaluru, India

    2 h-index

    5 publications

    207 citations

1–8 of 103

Venues

  1. Blood

    3 publications · 291 citations

    3

    h-index

  2. Nature Medicine

    2 publications · 556 citations

    2

    h-index

  3. Leukemia

    2 publications · 167 citations

    2

    h-index

  4. Cancer Research

    2 publications · 58 citations

    2

    h-index

  5. PLoS ONE

    1 publications · 13 citations

    1

    h-index

1–5