Concepedia

Enzyme-substrate Selectivity

Enzyme-Substrate Selectivity is a biochemical principle within enzyme kinetics that defines the preferential recognition and catalytic transformation of a specific substrate by an enzyme over other potential substrates, based on the structural and chemical complementarity between the enzyme's active site and the substrate.

1.1K

Publications

49.7K

Citations

4.8K

Authors

1.2K

Institutions

Publications per year

2017–2026

231

Parents

Publications

1.1K

Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

Harry G. Enoch, Ángel Catalá, Philipp Strittmatter · Journal of Biological Chemistry · 1976 · 560 citations · Full text

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Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System

Rati Verma, Robert Oania, Johannes Graumann et al. · Cell · 2004 · 453 citations · Full text

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Label‐Free Colorimetric Detection of Lead Ions with a Nanomolar Detection Limit and Tunable Dynamic Range by using Gold Nanoparticles and DNAzyme

Zidong Wang, Jung Heon Lee, Yi Lu · Advanced Materials · 2008 · 444 citations

, , +17

The collagen substrate specificity of human skin fibroblast collagenase.

Howard G. Welgus, John J. Jeffrey, Arthur Z. Eisen · Journal of Biological Chemistry · 1981 · 370 citations · Full text

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Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx

Keisuke Horiuchi, Sylvain Le Gall, Marc Schulte et al. · Molecular Biology of the Cell · 2006 · 309 citations · Full text

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1–5 of 1.1K

Authors

4.8K

  1. CJ
    Christopher J. Schofield

    University of Oxford, United Kingdom

    13 publications · 616 citations

    13

    h-index

  2. JO
    John O. Miners

    Flinders Medical Centre, Australia

    6 publications · 511 citations

    6

    h-index

  3. MM
    M.A. McDonough

    University of Oxford, United Kingdom

    6 publications · 217 citations

    6

    h-index

  4. IA
    I. A. NATCHEV

    Institute of Polymers, Bulgaria

    6 publications · 113 citations

    6

    h-index

  5. JA
    Jan A. Delcour

    KU Leuven, Belgium

    5 publications · 334 citations

    5

    h-index

1–5 of 4.8K

Institutions

1.2K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    24 h-index

    81 publications

    9.1K citations

  2. Chinese Academy of Sciences

    Beijing, China

    21 h-index

    127 publications

    5.8K citations

  3. University of Michigan

    Ann Arbor, United States

    20 h-index

    69 publications

    2.8K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    19 h-index

    124 publications

    6.3K citations

  5. University of Oxford

    Oxford, United Kingdom

    15 h-index

    102 publications

    5.6K citations

  6. University of Manchester

    Manchester, United Kingdom

    14 h-index

    50 publications

    3K citations

  7. Cornell University

    Ithaca, United States

    13 h-index

    33 publications

    1.5K citations

  8. University of California, San Francisco

    San Francisco, United States

    12 h-index

    32 publications

    1.5K citations

1–8 of 1.2K

Venues

  1. Journal of Biological Chemistry

    JBC · 109 publications · 8.1K citations

    53

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  2. Journal of the American Chemical Society

    JACS · 44 publications · 2.7K citations

    32

    h-index

  3. Biochemistry

    71 publications · 2.8K citations

    32

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 34 publications · 2.6K citations

    28

    h-index

  5. Biochemical Journal

    BJ · 28 publications · 1.2K citations

    21

    h-index

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