Concepedia

Enzyme-constrained Modeling

Enzyme-Constrained Modeling is a computational modeling framework in systems biology that incorporates enzymatic constraints, such as enzyme abundances and turnover rates, into metabolic models to more accurately predict metabolic fluxes and cellular phenotypes.

38

Publications

6.7K

Citations

189

Authors

84

Institutions

Publications per year

2017–2026

31

Parents

Publications

38

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

Jan Schellenberger, Richard Que, Ronan M. T. Fleming et al. · Nature Protocols · 2011 · 1.9K citations · Full text

, , +17

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Laurent Heirendt, Sylvain Arreckx, Thomas Pfau et al. · Nature Protocols · 2019 · 1.4K citations · Full text

, , +12

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox

Scott A. Becker, Adam M. Feist, Monica L. Mo et al. · Nature Protocols · 2007 · 804 citations

, , +17

Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

Benjamín J. Sánchez, Cheng Zhang, Avlant Nilsson et al. · Molecular Systems Biology · 2017 · 514 citations · Full text

, , +16

Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction

Feiran Li, Le Yuan, Hongzhong Lu et al. · Nature Catalysis · 2022 · 427 citations · Full text

, , +12

1–5 of 38

Authors

189

  1. JN
    Jens Nielsen

    Chalmers University of Technology, Sweden

    12 publications · 1.8K citations

    12

    h-index

  2. EJ
    Eduard J. Kerkhoven

    Chalmers University of Technology, Sweden

    8 publications · 1.6K citations

    8

    h-index

  3. BJ
    Benjamín J. Sánchez

    Chalmers University of Technology, Sweden

    7 publications · 1.3K citations

    7

    h-index

  4. ID
    Iván Domenzain

    Chalmers University of Technology, Sweden

    6 publications · 690 citations

    6

    h-index

  5. ZM
    Zhitao Mao

    Tianjin Institute of Industrial Biotechnology, China

    5 publications · 158 citations

    5

    h-index

1–5 of 189

Institutions

84

  1. Chalmers University of Technology

    Gothenburg, Sweden

    13 h-index

    72 publications

    12.8K citations

  2. BioInnovation Institute

    Copenhagen, Denmark

    9 h-index

    9 publications

    1.3K citations

  3. Technical University of Denmark

    Kongens Lyngby, Denmark

    8 h-index

    15 publications

    3.7K citations

  4. Novo Nordisk Foundation

    Copenhagen, Denmark

    8 h-index

    11 publications

    3.8K citations

  5. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    7 h-index

    42 publications

    1.4K citations

  6. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    41 publications

    1.3K citations

  7. East China University of Science and Technology

    Shanghai, China

    4 h-index

    12 publications

    976 citations

  8. University of California San Diego

    San Diego, United States

    3 h-index

    22 publications

    32.7K citations

1–8 of 84

Venues

  1. Nature Communications

    4 publications · 666 citations

    4

    h-index

  2. Metabolic Engineering

    4 publications · 157 citations

    4

    h-index

  3. Nature Protocols

    3 publications · 4.1K citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 148 citations

    3

    h-index

  5. Biomolecules

    2 publications · 71 citations

    2

    h-index

1–5