Concepedia

Enzyme Loop Dynamics

Enzyme Loop Dynamics is a structural and functional concept in protein science that refers to the conformational fluctuations and positional rearrangements of flexible loop regions within enzyme active sites, which modulate substrate binding, catalytic specificity, and reaction dynamics.

151

Publications

7.4K

Citations

603

Authors

275

Institutions

Publications per year

2017–2026

34

Parents

Publications

151

Loop and Subdomain Movements in the Mechanism of <i>Escherichia coli </i>Dihydrofolate Reductase:  Crystallographic Evidence<sup>,</sup>

M.R. Sawaya, Joseph Kraut · Biochemistry · 1997 · 666 citations

, , +17

Protein Dynamics in Enzymatic Catalysis:  Exploration of Dihydrofolate Reductase

Jennifer L. Radkiewicz, Charles L. Brooks · Journal of the American Chemical Society · 1999 · 316 citations

, , +17

Anatomy of a Conformational Change: Hinged "Lid" Motion of the Triosephosphate Isomerase Loop

Diane Joseph‐McCarthy, Gregory A. Petsko, Martin Karplus · Science · 1990 · 286 citations

, , +17

Backbone Dynamics in Dihydrofolate Reductase Complexes:  Role of Loop Flexibility in the Catalytic Mechanism

Michael J. Osborne, Jason R. Schnell, Stephen J. Benkovic et al. · Biochemistry · 2001 · 253 citations

, , +17

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

Dan McElheny, Jason R. Schnell, Jonathan C. Lansing et al. · Proceedings of the National Academy of Sciences · 2005 · 164 citations · Full text

, , +17

1–5 of 151

Authors

603

  1. SC
    Shina Caroline Lynn Kamerlin

    Uppsala University, Sweden

    6 publications · 369 citations

    6

    h-index

  2. PE
    Peter E. Wright

    Scripps Research Institute, United States

    6 publications · 719 citations

    6

    h-index

  3. HJ
    H. Jane Dyson

    Scripps Research Institute, United States

    5 publications · 595 citations

    5

    h-index

  4. JA
    J. Andrew McCammon

    University of California San Diego, United States

    5 publications · 325 citations

    5

    h-index

  5. AE
    Ann E. McDermott

    Columbia University, United States

    4 publications · 522 citations

    4

    h-index

1–5 of 603

Institutions

275

  1. Albert Einstein College of Medicine

    Bronx, United States

    8 h-index

    38 publications

    1.7K citations

  2. Scripps Research Institute

    San Diego, United States

    6 h-index

    24 publications

    3.8K citations

  3. Pennsylvania State University

    State College, United States

    6 h-index

    23 publications

    1.8K citations

  4. Columbia University

    New York, United States

    6 h-index

    17 publications

    1.6K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    22 publications

    682 citations

  6. Iowa State University

    Ames, United States

    5 h-index

    15 publications

    598 citations

  7. University of California San Diego

    San Diego, United States

    5 h-index

    16 publications

    2.3K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    12 publications

    995 citations

1–8 of 275

Venues

  1. Biochemistry

    44 publications · 2.7K citations

    28

    h-index

  2. Journal of Molecular Biology

    JMB · 9 publications · 605 citations

    9

    h-index

  3. Protein Science

    PS · 8 publications · 189 citations

    8

    h-index

  4. Journal of the American Chemical Society

    JACS · 8 publications · 855 citations

    8

    h-index

  5. The Journal of Physical Chemistry B

    5 publications · 85 citations

    5

    h-index

1–5