Concepedia

Enzyme Insensitivity

Enzyme Insensitivity is a molecular mechanism of target-site resistance in which a modified enzyme exhibits reduced binding affinity to a bioactive compound, thereby diminishing the compound's inhibitory effect while maintaining the enzyme's physiological function.

9

Publications

276

Citations

36

Authors

14

Institutions

Publications per year

2017–2026

0

Parents

Publications

9

Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation

Bryan F. Shaw, Grégory F. Schneider, Başar Bilgiçer et al. · Protein Science · 2008 · 74 citations · Full text

, , +17

The lysine-rich motif of intrinsically disordered stress protein CDeT11-24 from Craterostigma plantagineum is responsible for phosphatidic acid binding and protection of enzymes from damaging effects caused by desiccation

Jan Petersen, Sylvia Eriksson, Pia Harryson et al. · Journal of Experimental Botany · 2012 · 44 citations · Full text

, , +16

R86Q, a Mutation in <I>BmAChE3</I> Yielding a <I>Rhipicephalus microplus</I> Organophosphate-Insensitive Acetylcholinesterase

Kevin B. Temeyer, John H. Pruett, Pia U. Olafson et al. · Journal of Medical Entomology · 2007 · 35 citations

, , +13

R86Q, a Mutation in<i>BmAChE3</i>Yielding a<i>Rhipicephalus microplus</i>Organophosphate-Insensitive Acetylcholinesterase

Kevin B. Temeyer, John H. Pruett, Pia U. Olafson et al. · Journal of Medical Entomology · 2007 · 30 citations · Full text

, , +14

Vit C.Fe(III) induced loss of the covalently bound phosphate and enzyme activity of phosphoglucomutase.

Vijay Deshpande, J G Joshi · Journal of Biological Chemistry · 1985 · 27 citations · Full text

, , +14

1–5 of 9

Authors

36

  1. AC
    Andrew C. Chen

    Knipling-Bushland U.S. Livestock Insects Research Laboratory, United States

    2 publications · 65 citations

    2

    h-index

  2. KB
    Kevin B. Temeyer

    Knipling-Bushland U.S. Livestock Insects Research Laboratory, United States

    2 publications · 65 citations

    2

    h-index

  3. JH
    John H. Pruett

    Knipling-Bushland U.S. Livestock Insects Research Laboratory, United States

    2 publications · 65 citations

    2

    h-index

  4. PU
    Pia U. Olafson

    Knipling-Bushland U.S. Livestock Insects Research Laboratory, United States

    2 publications · 65 citations

    2

    h-index

  5. GB
    György Barabás

    Eötvös Loránd University, Hungary

    1 publications · 14 citations

    1

    h-index

1–5 of 36

Institutions

14

  1. Knipling-Bushland U.S. Livestock Insects Research Laboratory

    Kerrville, United States

    2 h-index

    8 publications

    260 citations

  2. Max Planck Institute for Plant Breeding Research

    Cologne, Germany

    1 h-index

    1 publications

    44 citations

  3. Stockholm University

    Stockholm, Sweden

    1 h-index

    2 publications

    88 citations

  4. University of California, Los Angeles

    Los Angeles, United States

    1 h-index

    1 publications

    74 citations

  5. Center for Systems Biology

    Boston, United States

    1 h-index

    2 publications

    148 citations

  6. University of Florida

    Gainesville, United States

    1 h-index

    5 publications

    105 citations

  7. Universidad de Buenos Aires

    Buenos Aires, Argentina

    1 h-index

    1 publications

    17 citations

  8. BioEnergetics (United States)

    Boston, United States

    1 h-index

    2 publications

    34 citations

1–8 of 14

Venues

  1. Journal of Medical Entomology

    2 publications · 65 citations

    2

    h-index

  2. Biochemical Genetics

    1 publications · 14 citations

    1

    h-index

  3. Free Radical Research

    1 publications · 17 citations

    1

    h-index

  4. Protein Science

    PS · 1 publications · 74 citations

    1

    h-index

  5. Journal of Biological Chemistry

    JBC · 1 publications · 27 citations

    1

    h-index

1–5