Concepedia

Enzymatic Assembly Lines

Enzymatic Assembly Lines is a biosynthetic framework in which multimodular enzymes sequentially catalyze reactions in a coordinated, assembly-line fashion to synthesize complex natural products, typically through polyketide synthase or nonribosomal peptide synthetase pathways.

54

Publications

5.5K

Citations

235

Authors

91

Institutions

Publications per year

2017–2026

23

Variants

Enzymatic Assembly-lines

Parents

Publications

54

antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation

Kai Blin, Simon J. Shaw, Hannah E. Augustijn et al. · Nucleic Acids Research · 2023 · 2.2K citations · Full text

, , +13

A singular enzymatic megacomplex from <i>Bacillus subtilis</i>

Paul D. Straight, Michael A. Fischbach, Christopher T. Walsh et al. · Proceedings of the National Academy of Sciences · 2006 · 187 citations · Full text

, , +14

Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization

Cathryn A. Shaw-Reid, Neil L. Kelleher, Heather C. Losey et al. · Chemistry & Biology · 1999 · 166 citations · Full text

, , +17

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

Michael A. Fischbach, Jonathan R. Lai, Eric Roche et al. · Proceedings of the National Academy of Sciences · 2007 · 143 citations · Full text

, , +16

Quantitative Analysis of the Relative Contributions of Donor Acyl Carrier Proteins, Acceptor Ketosynthases, and Linker Regions to Intermodular Transfer of Intermediates in Hybrid Polyketide Synthases

Nicholas Wu, David E. Cane, Chaitan Khosla · Biochemistry · 2002 · 130 citations

, , +15

1–5 of 54

Authors

235

  1. CT
    Christopher T. Walsh

    Harvard University, United States

    19 publications · 1.4K citations

    18

    h-index

  2. NL
    Neil L. Kelleher

    Northwestern University, United States

    6 publications · 433 citations

    6

    h-index

  3. CK
    Chaitan Khosla

    Stanford University, United States

    6 publications · 537 citations

    6

    h-index

  4. DE
    David E. Cane

    Brown University, United States

    5 publications · 451 citations

    5

    h-index

  5. MA
    Michael A. Fischbach

    Stanford University, United States

    4 publications · 386 citations

    4

    h-index

1–5 of 235

Institutions

91

  1. Harvard University

    Cambridge, United States

    19 h-index

    67 publications

    5.5K citations

  2. Stanford University

    Stanford, United States

    6 h-index

    31 publications

    2.7K citations

  3. Brown University

    Providence, United States

    5 h-index

    15 publications

    1.5K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    7 publications

    649 citations

  5. Philipps University of Marburg

    Marburg, Germany

    3 h-index

    11 publications

    808 citations

  6. University of California, Berkeley

    Berkeley, United States

    3 h-index

    12 publications

    330 citations

  7. University of Illinois Urbana-Champaign

    Urbana, United States

    3 h-index

    5 publications

    2.4K citations

  8. University of Warwick

    Coventry, United Kingdom

    3 h-index

    12 publications

    501 citations

1–8 of 91

Venues

  1. Biochemistry

    7 publications · 531 citations

    7

    h-index

  2. Journal of the American Chemical Society

    JACS · 6 publications · 420 citations

    6

    h-index

  3. Nature Communications

    5 publications · 341 citations

    5

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 434 citations

    4

    h-index

  5. Angewandte Chemie International Edition

    3 publications · 124 citations

    3

    h-index

1–5