Concepedia

Entropy-driven Binding

Entropy-Driven Binding is a thermodynamic mechanism of molecular recognition in which the favorable increase in total system entropy, often derived from the release of ordered solvent molecules or enhanced conformational flexibility upon complex formation, overcomes an enthalpic penalty and drives the association of intrinsically disordered proteins with their binding partners.

140

Publications

7.3K

Citations

619

Authors

271

Institutions

Publications per year

2017–2026

44

Parents

Publications

140

Binding of acylated peptides and fatty acids to phospholipid vesicles: Pertinence to myristoylated proteins

Robert M. Peitzsch, Stuart McLaughlin · Biochemistry · 1993 · 501 citations

, , +16

Thermodynamic Characterization of Polypeptide Complex Coacervation

Dimitrios Priftis, Nicolas Laugel, Matthew Tirrell · Langmuir · 2012 · 336 citations

, , +17

Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process.

Karl E. Kadler, Yoshio Hojima, Darwin J. Prockop · Journal of Biological Chemistry · 1987 · 325 citations · Full text

, , +16

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

Marta Amaral, Daria B. Kokh, Jörg Bomke et al. · Nature Communications · 2017 · 297 citations · Full text

, , +16

Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin

Nikolaos Georgelis, Neela H. Yennawar, Daniel J. Cosgrove · Proceedings of the National Academy of Sciences · 2012 · 195 citations · Full text

, , +17

1–5 of 140

Authors

619

  1. GS
    Gopinatha Suresh Kumar

    Indian Institute of Chemical Biology, India

    7 publications · 188 citations

    7

    h-index

  2. EV
    Eric V. Anslyn

    The University of Texas at Austin, United States

    4 publications · 303 citations

    4

    h-index

  3. AB
    Anirban Basu

    Indian Institute of Chemical Biology, India

    3 publications · 105 citations

    3

    h-index

  4. GK
    G. Klebe

    Philipps University of Marburg, Germany

    3 publications · 272 citations

    3

    h-index

  5. AH
    A. Heine

    Philipps University of Marburg, Germany

    3 publications · 272 citations

    3

    h-index

1–5 of 619

Institutions

271

  1. Indian Institute of Chemical Biology

    Kolkata, India

    8 h-index

    18 publications

    528 citations

  2. Philipps University of Marburg

    Marburg, Germany

    4 h-index

    13 publications

    1.2K citations

  3. Heidelberg University

    Heidelberg, Germany

    4 h-index

    10 publications

    705 citations

  4. Karlsruhe Institute of Technology

    Karlsruhe, Germany

    3 h-index

    7 publications

    308 citations

  5. University of California, Berkeley

    Berkeley, United States

    3 h-index

    9 publications

    1.2K citations

  6. Lawrence Berkeley National Laboratory

    Berkeley, United States

    3 h-index

    6 publications

    456 citations

  7. University of Toronto

    Toronto, Canada

    3 h-index

    8 publications

    490 citations

  8. The University of Texas at Austin

    Austin, United States

    3 h-index

    8 publications

    410 citations

1–8 of 271

Venues

  1. Biochemistry

    12 publications · 916 citations

    11

    h-index

  2. Journal of the American Chemical Society

    JACS · 9 publications · 741 citations

    9

    h-index

  3. Journal of Biological Chemistry

    JBC · 6 publications · 535 citations

    6

    h-index

  4. The Journal of Physical Chemistry B

    5 publications · 192 citations

    5

    h-index

  5. Journal of Molecular Biology

    JMB · 5 publications · 288 citations

    5

    h-index

1–5