Concepedia

Enhancer Dysregulation

Enhancer Dysregulation is a pathogenic alteration in the activity of cis-regulatory DNA elements that control gene expression in a spatial, temporal, or cell-type-specific manner, characterized by aberrant enhancer activation or silencing that disrupts normal transcriptional programs in cancer.

37

Publications

2.2K

Citations

442

Authors

141

Institutions

Publications per year

2017–2026

25

Parents

Publications

37

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

Hunain Alam, Ming Tang, Mayinuer Maitituoheti et al. · Cancer Cell · 2020 · 244 citations · Full text

, , +14

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

Tim D.D. Somerville, Yali Xu, Koji Miyabayashi et al. · Cell Reports · 2018 · 234 citations · Full text

, , +17

Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease

Sumantra Chatterjee, Ashish Kapoor, Jennifer A. Akiyama et al. · Cell · 2016 · 149 citations · Full text

, , +17

Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma

Russell J.H. Ryan, Yotam Drier, Holly Whitton et al. · Cancer Discovery · 2015 · 132 citations · Full text

, , +15

DiseaseEnhancer: a resource of human disease-associated enhancer catalog

Guanxiong Zhang, Jian Shi, Shiwei Zhu et al. · Nucleic Acids Research · 2017 · 95 citations · Full text

, , +14

1–5 of 37

Authors

442

  1. CA
    Christopher A. Haiman

    University of Southern California, United States

    2 publications · 71 citations

    2

    h-index

  2. YD
    Yotam Drier

    Massachusetts General Hospital, United States

    2 publications · 144 citations

    2

    h-index

  3. RS
    Ranveer Singh Jayani

    National Centre for Cell Science, India

    2 publications · 83 citations

    2

    h-index

  4. PT
    Patrick Tan

    Duke-NUS Medical School, Singapore

    2 publications · 37 citations

    2

    h-index

  5. EM
    Eugene M. Oltz

    The Ohio State University, United States

    1 publications · 92 citations

    1

    h-index

1–5 of 442

Institutions

141

  1. Princess Margaret Cancer Centre

    Toronto, Canada

    3 h-index

    7 publications

    234 citations

  2. Sun Yat-sen University

    Guangzhou, China

    3 h-index

    32 publications

    573 citations

  3. University of Toronto

    Toronto, Canada

    3 h-index

    6 publications

    138 citations

  4. University Health Network

    Toronto, Canada

    3 h-index

    6 publications

    176 citations

  5. National University Cancer Institute, Singapore

    Singapore, Singapore

    3 h-index

    18 publications

    983 citations

  6. National University of Singapore

    Singapore, Singapore

    3 h-index

    17 publications

    880 citations

  7. Duke-NUS Medical School

    Singapore, Singapore

    2 h-index

    9 publications

    184 citations

  8. Kyushu University

    Fukuoka, Japan

    2 h-index

    8 publications

    452 citations

1–8 of 141

Venues

  1. Nature Communications

    6 publications · 336 citations

    6

    h-index

  2. Cell Reports

    3 publications · 294 citations

    3

    h-index

  3. Nucleic Acids Research

    2 publications · 115 citations

    2

    h-index

  4. Cancer Discovery

    2 publications · 201 citations

    2

    h-index

  5. Cancer Cell

    2 publications · 324 citations

    2

    h-index

1–5