Concepedia

Efflux Pump Evolution

Efflux Pump Evolution is a molecular adaptation mechanism in which microorganisms develop enhanced capacity to expel antimicrobial agents through genetically modified or overexpressed transmembrane transporter proteins, thereby reducing intracellular drug concentrations and conferring resistance within evolving bacterial populations.

54

Publications

4.1K

Citations

312

Authors

136

Institutions

Publications per year

2017–2026

31

Parents

Publications

54

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

Benjamin K. Chan, Mark Sistrom, John E. Wertz et al. · Scientific Reports · 2016 · 722 citations · Full text

, , +17

Complete Sequence of a 184-Kilobase Catabolic Plasmid from <i>Sphingomonas aromaticivorans</i> F199

Margaret F. Romine, Lisa C. Stillwell, Kwong‐Kwok Wong et al. · Journal of Bacteriology · 1999 · 315 citations · Full text

, , +15

RND multidrug efflux pumps: what are they good for?

Carolina Alvarez‐Ortega, Jorge Olivares‐Pacheco, José Luis Martínez · Frontiers in Microbiology · 2013 · 222 citations · Full text

, , +17

Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates

Gabriel Cabot, Laura Zamorano, Bartolomé Moyá et al. · Antimicrobial Agents and Chemotherapy · 2016 · 209 citations · Full text

, , +17

Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps

Jason M. Johnson, George M. Church · Journal of Molecular Biology · 1999 · 180 citations

, , +17

1–5 of 54

Authors

312

  1. IT
    Ian T. Paulsen

    Macquarie University, Australia

    5 publications · 189 citations

    5

    h-index

  2. KA
    Karl A. Hassan

    Macquarie University, Australia

    4 publications · 143 citations

    4

    h-index

  3. VN
    Varsha Naidu

    University of Newcastle Australia, Australia

    3 publications · 99 citations

    3

    h-index

  4. DH
    Daniel H. F. Rubin

    Harvard University, United States

    2 publications · 96 citations

    2

    h-index

  5. SR
    Simon R. Harris

    Wellcome Sanger Institute, United Kingdom

    2 publications · 96 citations

    2

    h-index

1–5 of 312

Institutions

136

  1. Macquarie University

    Sydney, Australia

    4 h-index

    21 publications

    789 citations

  2. Centro Nacional de Biotecnología

    Madrid, Spain

    3 h-index

    8 publications

    1.2K citations

  3. University of Newcastle Australia

    Newcastle, Australia

    3 h-index

    8 publications

    218 citations

  4. South China Agricultural University

    Guangzhou, China

    3 h-index

    13 publications

    420 citations

  5. Harvard University

    Cambridge, United States

    3 h-index

    14 publications

    936 citations

  6. University of California, Berkeley

    Berkeley, United States

    2 h-index

    7 publications

    772 citations

  7. Brigham and Women's Hospital

    Boston, United States

    2 h-index

    2 publications

    96 citations

  8. Wellcome Sanger Institute

    Cambridge, United Kingdom

    2 h-index

    4 publications

    192 citations

1–8 of 136

Venues

  1. Journal of Antimicrobial Chemotherapy

    JAC · 5 publications · 218 citations

    5

    h-index

  2. PLoS ONE

    4 publications · 171 citations

    4

    h-index

  3. Frontiers in Microbiology

    4 publications · 299 citations

    4

    h-index

  4. Scientific Reports

    3 publications · 793 citations

    3

    h-index

  5. PubMed

    Repository · 3 publications · 164 citations

    3

    h-index

1–5