Concepedia

Drug Basicity

Drug Basicity is a chemical property that characterizes the tendency of a drug molecule to accept protons and become protonated, distinguishing it by its influence on the drug’s distribution, ionization state, and postmortem redistribution behavior in biological matrices.

16

Publications

1.1K

Citations

86

Authors

23

Institutions

Publications per year

2017–2026

2

Parents

Publications

16

The pK(a) Distribution of Drugs: Application to Drug Discovery.

David T. Manallack · PubMed · 2007 · 218 citations

, , +12

The p<i>K</i><sub>a</sub>Distribution of Drugs: Application to Drug Discovery

David T. Manallack · Perspectives in Medicinal Chemistry · 2007 · 205 citations · Full text

, , +11

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

Zhaoning Zhu, Z. J. Sun, Yuanzan Ye et al. · Journal of Medicinal Chemistry · 2009 · 121 citations · Full text

, , +17

Binding of basic and acidic drugs to rat tissue subcellular fractions

Marcel H. Bickel, James Steele · Chemico-Biological Interactions · 1974 · 79 citations

, , +14

The acid–base profile of a contemporary set of drugs: implications for drug discovery

David T. Manallack · SAR and QSAR in environmental research · 2009 · 78 citations

, , +11

1–5 of 16

Authors

86

  1. DT
    David T. Manallack

    Monash University, Australia

    3 publications · 501 citations

    3

    h-index

  2. RM
    Robert McKenna

    University of Florida, United States

    1 publications · 46 citations

    1

    h-index

  3. CG
    C. George DeGrazia

    1 publications · 15 citations

    1

    h-index

  4. ML
    Marcello Leopoldo

    University of Bari Aldo Moro, Italy

    1 publications · 48 citations

    1

    h-index

  5. JE
    James E. Dunford

    University of Oxford, United Kingdom

    1 publications · 71 citations

    1

    h-index

1–5 of 86

Institutions

23

  1. Monash University

    Melbourne, Australia

    3 h-index

    3 publications

    501 citations

  2. University of Palermo

    Palermo, Italy

    1 h-index

    18 publications

    1.3K citations

  3. Bielefeld University

    Bielefeld, Germany

    1 h-index

    2 publications

    48 citations

  4. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    1 h-index

    2 publications

    46 citations

  5. Université Côte d'Azur

    Nice, France

    1 h-index

    5 publications

    130 citations

  6. Universidad Nacional de Colombia

    Bogotá, Colombia

    1 h-index

    1 publications

    23 citations

  7. École Polytechnique

    Palaiseau, France

    1 h-index

    4 publications

    120 citations

  8. University of Bern

    Bern, Switzerland

    1 h-index

    2 publications

    158 citations

1–8 of 23

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 207 citations

    3

    h-index

  2. Scientia Pharmaceutica

    1 publications · 23 citations

    1

    h-index

  3. The Journal of Organic Chemistry

    JOC · 1 publications · 26 citations

    1

    h-index

  4. PubMed

    Repository · 1 publications · 218 citations

    1

    h-index

  5. Dalton Transactions

    1 publications · 40 citations

    1

    h-index

1–5