Concepedia

Drosha Cleavage

Drosha Cleavage is a catalytic processing event in which the RNase III enzyme Drosha selectively cleaves primary microRNA transcripts within the nucleus to liberate precursor microRNA hairpins, marking the inaugural step in the canonical microRNA biogenesis pathway.

145

Publications

26.6K

Citations

795

Authors

278

Institutions

Publications per year

2017–2026

28

Parents

Publications

145

The nuclear RNase III Drosha initiates microRNA processing

Yoontae Lee, Chiyoung Ahn, Jinju Han et al. · Nature · 2003 · 5.1K citations

, , +11

The Drosha-DGCR8 complex in primary microRNA processing

Jinju Han, Yoontae Lee, Kyu-Hyun Yeom et al. · Genes & Development · 2004 · 2.2K citations · Full text

, , +17

Intronic microRNA precursors that bypass Drosha processing

J. Graham Ruby, Calvin H. Jan, David P. Bartel · Nature · 2007 · 1.6K citations · Full text

, , +13

Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex

Jinju Han, Yoontae Lee, Kyu‐Hyeon Yeom et al. · Cell · 2006 · 1.5K citations · Full text

, , +13

SMAD proteins control DROSHA-mediated microRNA maturation

Brandi N. Davis‐Dusenbery, Aaron C. Hilyard, Giorgio Lagna et al. · Nature · 2008 · 1.2K citations · Full text

, , +9

1–5 of 145

Authors

795

  1. VN
    V. Narry Kim

    Seoul National University, South Korea

    7 publications · 7.3K citations

    7

    h-index

  2. TA
    Tuan Anh Nguyen

    Hong Kong University of Science and Technology, Hong Kong SAR China

    7 publications · 439 citations

    6

    h-index

  3. TD
    Trung Duc Nguyen

    Hong Kong University of Science and Technology, Hong Kong SAR China

    7 publications · 221 citations

    6

    h-index

  4. MM
    Mark M. W. Chong

    Walter and Eliza Hall Institute of Medical Research, Australia

    6 publications · 990 citations

    6

    h-index

  5. YZ
    Yan Zeng

    Chinese Academy of Sciences, China

    5 publications · 1.1K citations

    5

    h-index

1–5 of 795

Institutions

278

  1. Seoul National University

    Seoul, South Korea

    15 h-index

    70 publications

    68.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    34 publications

    14.7K citations

  3. The University of Texas Southwestern Medical Center

    Dallas, United States

    6 h-index

    32 publications

    4.2K citations

  4. Hong Kong University of Science and Technology

    Hong Kong, Hong Kong

    6 h-index

    28 publications

    854 citations

  5. University of Hong Kong

    Pok Fu Lam, Hong Kong

    6 h-index

    25 publications

    834 citations

  6. Heidelberg University

    Heidelberg, Germany

    5 h-index

    22 publications

    2.7K citations

  7. Institute for Basic Science

    Daejeon, South Korea

    5 h-index

    19 publications

    2.1K citations

  8. Duke Medical Center

    Durham, United States

    4 h-index

    14 publications

    2.8K citations

1–8 of 278

Venues

  1. Nucleic Acids Research

    14 publications · 1.3K citations

    14

    h-index

  2. RNA

    11 publications · 558 citations

    11

    h-index

  3. Molecular Cell

    8 publications · 1.6K citations

    8

    h-index

  4. RNA Biology

    8 publications · 406 citations

    8

    h-index

  5. PLoS ONE

    6 publications · 429 citations

    6

    h-index

1–5