Concepedia

Double-stranded Rna Sensing

Double-Stranded RNA Sensing is a molecular recognition mechanism in innate immunity whereby cytoplasmic pattern recognition receptors specifically detect double-stranded RNA structures as pathogen-associated molecular patterns to initiate antiviral signaling cascades.

279

Publications

38.5K

Citations

2.2K

Authors

620

Institutions

Publications per year

2017–2026

111

Parents

Publications

279

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov et al. · Nature · 2001 · 6.1K citations

, , +14

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.9K citations

, , +16

RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

Andreas Pichlmair, Oliver Schulz, Choon Ping Tan et al. · Science · 2006 · 2.2K citations

, , +17

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Brian Liddicoat, Robert Piskol, Alistair M. Chalk et al. · Science · 2015 · 999 citations · Full text

, , +15

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Katalin Karikó, Hiromi Muramatsu, János Ludwig et al. · Nucleic Acids Research · 2011 · 884 citations · Full text

, , +15

1–5 of 279

Authors

2.2K

  1. TF
    Takashi Fujita

    Kyoto University, Japan

    7 publications · 4.7K citations

    8

    h-index

  2. SR
    Susan R. Weiss

    University of Pennsylvania, United States

    6 publications · 714 citations

    7

    h-index

  3. RH
    Robert H. Silverman

    Cleveland Clinic, United States

    7 publications · 824 citations

    7

    h-index

  4. SA
    Shizuo Akira

    The University of Osaka, Japan

    5 publications · 4.9K citations

    5

    h-index

  5. HK
    Hiroki Kato

    Kyoto University, Japan

    4 publications · 201 citations

    5

    h-index

1–5 of 2.2K

Institutions

620

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    35 publications

    18.4K citations

  2. Harvard University

    Cambridge, United States

    10 h-index

    34 publications

    6.7K citations

  3. Cleveland Clinic

    Cleveland, United States

    10 h-index

    32 publications

    6.4K citations

  4. Kyoto University

    Kyoto, Japan

    10 h-index

    35 publications

    2.4K citations

  5. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    24 publications

    5.7K citations

  6. Cleveland Clinic Lerner College of Medicine

    Cleveland, United States

    9 h-index

    25 publications

    3.3K citations

  7. Emory University

    Atlanta, United States

    8 h-index

    25 publications

    1.6K citations

  8. University of Bonn

    Bonn, Germany

    8 h-index

    36 publications

    10.4K citations

1–8 of 620

Venues

  1. Journal of Virology

    JVI · 17 publications · 1.3K citations

    17

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 3.1K citations

    16

    h-index

  3. Journal of Biological Chemistry

    JBC · 16 publications · 2.4K citations

    15

    h-index

  4. The Journal of Immunology

    JI · 11 publications · 1.3K citations

    11

    h-index

  5. Nucleic Acids Research

    7 publications · 1.1K citations

    7

    h-index

1–5