Concepedia

Dose Intensity Optimization

Dose Intensity Optimization is a methodological framework within dose modification strategies that systematically balances therapeutic efficacy and toxicity by maximizing the delivered drug intensity relative to the planned regimen while adhering to safety constraints.

75

Publications

3.4K

Citations

591

Authors

232

Institutions

Publications per year

2017–2026

16

Parents

Publications

75

Average relative dose intensity and the impact on design of clinical trials.

W M Hryniuk · PubMed · 1987 · 229 citations

, , +12

Assessment of dose-intensive therapy in suboptimally debulked ovarian cancer: a Gynecologic Oncology Group study.

William P. McGuire, William J. Hoskins, Mark F. Brady et al. · Journal of Clinical Oncology · 1995 · 221 citations

, , +16

Impact of early dose intensity on cytogenetic and molecular responses in chronic- phase CML patients receiving 600 mg/day of imatinib as initial therapy

Timothy P. Hughes, Susan Branford, Deborah L. White et al. · Blood · 2008 · 177 citations · Full text

, , +10

Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer.

K. Thomas Robbins, Anna Maria Storniolo, Charles W. Kerber et al. · Journal of Clinical Oncology · 1994 · 166 citations

, , +17

Can cytotoxic dose-intensity be increased by using granulocyte colony-stimulating factor? A randomized controlled trial of lenograstim in small-cell lung cancer.

Penella J. Woll, Jackie Hodgetts, Lynn Lomax et al. · Journal of Clinical Oncology · 1995 · 129 citations

, , +17

1–5 of 75

Authors

591

  1. SB
    Stephen B. Howell

    University of California San Diego, United States

    2 publications · 203 citations

    2

    h-index

  2. EL
    Edward L. Korn

    National Cancer Institute, United States

    2 publications · 67 citations

    2

    h-index

  3. PH
    Peter Harper

    Guy's Hospital, United Kingdom

    2 publications · 94 citations

    2

    h-index

  4. HD
    Hervé Dombret

    Hôpital Saint-Louis, France

    2 publications · 38 citations

    2

    h-index

  5. KT
    Kazuhisa Toda

    The Cancer Institute Hospital, Japan

    2 publications · 83 citations

    2

    h-index

1–5 of 591

Institutions

232

  1. National Cancer Institute

    Bethesda, United States

    4 h-index

    27 publications

    757 citations

  2. University of California San Diego

    San Diego, United States

    3 h-index

    9 publications

    534 citations

  3. Institut Paoli-Calmettes

    Marseille, France

    3 h-index

    7 publications

    120 citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    3 h-index

    15 publications

    378 citations

  5. The Cancer Institute Hospital

    Tokyo, Japan

    2 h-index

    14 publications

    356 citations

  6. Cancer Research UK

    London, United Kingdom

    2 h-index

    7 publications

    333 citations

  7. Radiation Oncology Associates

    Fort Wayne, United States

    2 h-index

    3 publications

    191 citations

  8. University Hospital of Ioannina

    Ioannina, Greece

    2 h-index

    2 publications

    51 citations

1–8 of 232

Venues

  1. Journal of Clinical Oncology

    8 publications · 904 citations

    8

    h-index

  2. PubMed

    Repository · 6 publications · 331 citations

    6

    h-index

  3. Blood

    4 publications · 277 citations

    4

    h-index

  4. Cancer

    3 publications · 84 citations

    3

    h-index

  5. Annals of Oncology

    3 publications · 90 citations

    3

    h-index

1–5