Concepedia

Dnase Therapy

DNase Therapy is a therapeutic method that employs deoxyribonuclease enzymes to selectively degrade extracellular DNA in pathological secretions, thereby reducing viscosity and improving respiratory function in conditions such as cystic fibrosis.

173

Publications

10.9K

Citations

937

Authors

386

Institutions

Publications per year

2017–2026

49

Parents

Publications

173

Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis

Henry J. Fuchs, Drucy Borowitz, David Høyrup Christiansen et al. · New England Journal of Medicine · 1994 · 1.5K citations · Full text

, , +14

Treatment of Idiopathic Bronchiectasis With Aerosolized Recombinant Human DNase I

Anne E. O’Donnell, Alan F. Barker, Jonathan Ilowite et al. · CHEST Journal · 1998 · 440 citations · Full text

, , +12

Resolution of mucus plugging and atelectasis after intratracheal rhDNase therapy in a mechanically ventilated child with refractory status asthmaticus

Andrew Durward, Vito Forte, Sam D. Shemie · Critical Care Medicine · 2000 · 264 citations

, , +17

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

Venizelos Papayannopoulos, Doris Staab, Arturo Zychlinsky · PLoS ONE · 2011 · 256 citations · Full text

, , +17

Efficacy and Safety of Short-term Administration of Aerosolized Recombinant Human Deoxyribonuclease in Patients with Cystic Fibrosis

Bonnie W. Ramsey, Susan J. Astley, Moira L. Aitken et al. · American Review of Respiratory Disease · 1993 · 234 citations

, , +14

1–5 of 173

Authors

937

  1. PM
    Peter Merkus

    Radboud University Nijmegen, Netherlands

    5 publications · 271 citations

    5

    h-index

  2. SS
    Sandra Scott

    Royal Brompton Hospital, United Kingdom

    4 publications · 284 citations

    4

    h-index

  3. JC
    Johan C. de Jongste

    Erasmus MC, Netherlands

    4 publications · 160 citations

    4

    h-index

  4. PL
    Pallav L. Shah

    Imperial College London, United Kingdom

    4 publications · 284 citations

    4

    h-index

  5. SS
    Steven Shak

    Genomic Health (United States), United States

    4 publications · 556 citations

    4

    h-index

1–5 of 937

Institutions

386

  1. Royal Brompton Hospital

    London, United Kingdom

    9 h-index

    46 publications

    4.4K citations

  2. Harvard University

    Cambridge, United States

    8 h-index

    28 publications

    1.3K citations

  3. Erasmus MC - Sophia Children’s Hospital

    Rotterdam, The Netherlands

    7 h-index

    22 publications

    1K citations

  4. Boston Children's Hospital

    Boston, United States

    7 h-index

    11 publications

    1.9K citations

  5. University of Washington

    Seattle, United States

    5 h-index

    5 publications

    482 citations

  6. Inserm

    Paris, France

    4 h-index

    13 publications

    377 citations

  7. Medizinische Hochschule Hannover

    Hanover, Germany

    4 h-index

    17 publications

    627 citations

  8. Massachusetts General Hospital

    Boston, United States

    4 h-index

    6 publications

    235 citations

1–8 of 386

Venues

  1. Pediatric Pulmonology

    12 publications · 736 citations

    12

    h-index

  2. European Respiratory Journal

    7 publications · 411 citations

    7

    h-index

  3. Thorax

    7 publications · 527 citations

    7

    h-index

  4. PubMed

    Repository · 6 publications · 319 citations

    6

    h-index

  5. Scientific Reports

    5 publications · 206 citations

    5

    h-index

1–5