Concepedia

Dissolution-limited Bioavailability

Dissolution-Limited Bioavailability is a pharmacokinetic phenomenon in which the rate and extent of drug absorption are constrained by the slow dissolution of the drug in the gastrointestinal fluid, thereby limiting its availability for systemic absorption.

187

Publications

14.3K

Citations

802

Authors

229

Institutions

Publications per year

2017–2026

44

Parents

Publications

187

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research · 1995 · 5.3K citations · Full text

, , +16

Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

Ryusuke Takano, Kiyohiko Sugano, Atsuko Higashida et al. · Pharmaceutical Research · 2006 · 277 citations

, , +17

Micronization: A method of improving the bioavailability of poorlysoluble drugs

J.C. Chaumeil · Methods and Findings in Experimental and Clinical Pharmacology · 1998 · 240 citations

, , +16

Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs Via Solid Solutions and Eutectic Mixtures I

Arthur H. Goldberg, Milo Gibaldi, Joseph L. Kanig · Journal of Pharmaceutical Sciences · 1965 · 222 citations

, , +17

Discovery of 4-Benzoyl-1-[(4-methoxy-1<i>H</i>- pyrrolo[2,3-<i>b</i>]pyridin-3-yl)oxoacetyl]-2- (<i>R</i>)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions

Tao Wang, Zhongxing Zhang, Owen B. Wallace et al. · Journal of Medicinal Chemistry · 2003 · 206 citations

, , +17

1–5 of 187

Authors

802

  1. AE
    Akira Ejima

    National Institute of Health Sciences, Japan

    6 publications · 97 citations

    6

    h-index

  2. NK
    Nahoko Kaniwa

    National Institute of Health Sciences, Japan

    6 publications · 98 citations

    6

    h-index

  3. NA
    N Aoyagi

    National Institute of Health Sciences, Japan

    5 publications · 67 citations

    5

    h-index

  4. SY
    Shinji Yamashita

    Setsunan University, Japan

    5 publications · 634 citations

    5

    h-index

  5. AH
    Arthur H. Goldberg

    University of Michigan, United States

    4 publications · 667 citations

    4

    h-index

1–5 of 802

Institutions

229

  1. University of Michigan

    Ann Arbor, United States

    7 h-index

    14 publications

    6.1K citations

  2. United States Food and Drug Administration

    Silver Spring, United States

    7 h-index

    19 publications

    669 citations

  3. Setsunan University

    Osaka, Japan

    5 h-index

    18 publications

    1.6K citations

  4. Shenyang Pharmaceutical University

    Shenyang, China

    5 h-index

    28 publications

    1.1K citations

  5. AstraZeneca (Sweden)

    Södertälje, Sweden

    5 h-index

    11 publications

    228 citations

  6. Bristol-Myers Squibb (United States)

    New York, United States

    4 h-index

    62 publications

    6.6K citations

  7. Columbia University

    New York, United States

    4 h-index

    13 publications

    2.1K citations

  8. National and Kapodistrian University of Athens

    Athens, Greece

    4 h-index

    9 publications

    400 citations

1–8 of 229

Venues

  1. Journal of Pharmaceutical Sciences

    21 publications · 1.4K citations

    18

    h-index

  2. International Journal of Pharmaceutics

    16 publications · 664 citations

    15

    h-index

  3. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 13 publications · 471 citations

    13

    h-index

  4. European Journal of Pharmaceutical Sciences

    12 publications · 640 citations

    12

    h-index

  5. PubMed

    Repository · 10 publications · 157 citations

    10

    h-index

1–5