Concepedia

Dickkopf Proteins

Dickkopf Proteins is a family of secreted glycoproteins that act as extracellular antagonists of the Wnt signaling pathway by specifically binding to the LRP5/6 co-receptors, thereby inhibiting Wnt/β-catenin signaling and playing critical regulatory roles in embryonic development and tissue homeostasis.

495

Publications

35.9K

Citations

3.4K

Authors

939

Institutions

Publications per year

2017–2026

188

Variants

Dkk Proteins

Parents

Publications

495

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Andrei Glinka, Wei Wu, Hajo Delius et al. · Nature · 1998 · 1.6K citations

, , +4

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Erming Tian, Fenghuang Zhan, Ronald C. Walker et al. · New England Journal of Medicine · 2003 · 1.5K citations · Full text

, , +17

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Bingyu Mao, Wei Wu, Yan Li et al. · Nature · 2001 · 1K citations

, , +5

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Bingyu Mao, Wei Wu, Gary Davidson et al. · Nature · 2002 · 1K citations

, , +12

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Alfiya Akhmetshina, Katrin Palumbo, Clara Dees et al. · Nature Communications · 2012 · 831 citations · Full text

, , +15

1–5 of 495

Authors

3.4K

  1. CN
    Christof Niehrs

    DKFZ-ZMBH Alliance, Germany

    23 publications · 5.9K citations

    22

    h-index

  2. MR
    Martina Rauner

    Technische Universität Dresden, Germany

    10 publications · 347 citations

    10

    h-index

  3. LC
    Lorenz C. Hofbauer

    Technische Universität Dresden, Germany

    10 publications · 347 citations

    10

    h-index

  4. TD
    Tilman D. Rachner

    Technische Universität Dresden, Germany

    6 publications · 236 citations

    6

    h-index

  5. JM
    José Manuel González‐Sancho

    Consejo Superior de Investigaciones Científicas, Spain

    6 publications · 1.1K citations

    6

    h-index

1–5 of 3.4K

Institutions

939

  1. German Cancer Research Center

    Heidelberg, Germany

    22 h-index

    88 publications

    36.7K citations

  2. Heidelberg University

    Heidelberg, Germany

    19 h-index

    64 publications

    6K citations

  3. DKFZ-ZMBH Alliance

    Heidelberg, Germany

    18 h-index

    80 publications

    36.9K citations

  4. Sun Yat-sen University

    Guangzhou, China

    12 h-index

    99 publications

    3.6K citations

  5. National Institutes of Health

    Bethesda, United States

    11 h-index

    49 publications

    5.2K citations

  6. Shanghai Jiao Tong University

    Shanghai, China

    11 h-index

    66 publications

    1.6K citations

  7. Technische Universität Dresden

    Dresden, Germany

    10 h-index

    66 publications

    2.5K citations

  8. The University of Osaka

    Osaka, Japan

    9 h-index

    47 publications

    3.8K citations

1–8 of 939

Venues

  1. PLoS ONE

    22 publications · 945 citations

    18

    h-index

  2. PubMed

    Repository · 15 publications · 573 citations

    13

    h-index

  3. Oncotarget

    12 publications · 450 citations

    12

    h-index

  4. Journal of Biological Chemistry

    JBC · 11 publications · 1.2K citations

    11

    h-index

  5. Development

    11 publications · 1.3K citations

    11

    h-index

1–5