Concepedia

Destruction Complex

The Destruction Complex is a multiprotein complex that functions in the Wnt signaling pathway by targeting β-catenin for proteasomal degradation through phosphorylation, thereby maintaining low cytoplasmic levels of β-catenin in the absence of Wnt ligand.

149

Publications

13.3K

Citations

971

Authors

308

Institutions

Publications per year

2017–2026

57

Variants

β-Catenin Destruction Complex

Parents

Publications

149

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

Luca Azzolin, Tito Panciera, Sandra Soligo et al. · Cell · 2014 · 1.1K citations · Full text

, , +9

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

Jeffrey Winston, Peter R. Strack, Peggy Beer‐Romero et al. · Genes & Development · 1999 · 946 citations · Full text

, , +12

Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis

Hui Zou, Thomas J. McGarry, Teresita U. Bernal et al. · Science · 1999 · 813 citations

, , +17

Wnt Signaling Controls the Phosphorylation Status of β-Catenin

Mascha van Noort, Jan Meeldijk, Ruurd van der Zee et al. · Journal of Biological Chemistry · 2002 · 469 citations · Full text

, , +15

Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

Michael B. Major, Nathan D. Camp, Jason D. Berndt et al. · Science · 2007 · 413 citations

, , +17

1–5 of 149

Authors

971

  1. YA
    Yashi Ahmed

    Dartmouth College, United States

    8 publications · 297 citations

    8

    h-index

  2. OT
    Ofelia Tacchelly‐Benites

    Dartmouth College, United States

    5 publications · 220 citations

    5

    h-index

  3. EY
    Eungi Yang

    Dartmouth College, United States

    5 publications · 220 citations

    5

    h-index

  4. DM
    David M. Roberts

    Franklin & Marshall College, United States

    5 publications · 200 citations

    5

    h-index

  5. EL
    Ethan Lee

    Vanderbilt University Medical Center, United States

    5 publications · 227 citations

    5

    h-index

1–5 of 971

Institutions

308

  1. Oslo University Hospital

    Oslo, Norway

    8 h-index

    45 publications

    7.2K citations

  2. Dartmouth College

    Hanover, United States

    8 h-index

    40 publications

    1.6K citations

  3. Stanford University

    Stanford, United States

    6 h-index

    31 publications

    2.3K citations

  4. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    19 publications

    1.8K citations

  5. Franklin & Marshall College

    Lancaster, United States

    5 h-index

    12 publications

    428 citations

  6. Harvard University

    Cambridge, United States

    5 h-index

    16 publications

    5.5K citations

  7. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    5 h-index

    29 publications

    1.1K citations

  8. University of Oslo

    Oslo, Norway

    5 h-index

    30 publications

    6.6K citations

1–8 of 308

Venues

  1. Molecular and Cellular Biology

    MCB · 8 publications · 876 citations

    8

    h-index

  2. PLoS ONE

    7 publications · 302 citations

    7

    h-index

  3. Journal of Biological Chemistry

    JBC · 6 publications · 855 citations

    6

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 406 citations

    5

    h-index

  5. Genes & Development

    5 publications · 1.6K citations

    5

    h-index

1–5