Concepedia

Desensitization Kinetics

Desensitization Kinetics is a biophysical construct that characterizes the time-dependent decline in ion channel responsiveness following prolonged or repeated agonist exposure, distinguishing it from related kinetic processes such as inactivation or deactivation by specifically describing the rate and mechanism of functional unresponsiveness intrinsic to ligand-gated ion channels.

306

Publications

18.9K

Citations

979

Authors

309

Institutions

Publications per year

2017–2026

11

Parents

Publications

306

Desensitized states prolong GABAA channel responses to brief agonist pulses

Mathew V. Jones, Gary L. Westbrook · Neuron · 1995 · 589 citations · Full text

, , +14

NMDA channel behavior depends on agonist affinity

R.A.J. Lester, CE Jahr · Journal of Neuroscience · 1992 · 401 citations · Full text

, , +17

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

Jochen Schwenk, Nadine Harmel, Gerd Zolles et al. · Science · 2009 · 384 citations

, , +17

Influence of Subunit Composition on Desensitization of Neuronal Acetylcholine Receptors at Low Concentrations of Nicotine

Catherine P. Fenster, Mike Rains, Brett D. Noerager et al. · Journal of Neuroscience · 1997 · 341 citations · Full text

, , +17

TRPV1 shows dynamic ionic selectivity during agonist stimulation

Man‐Kyo Chung, Ali D. Güler, Michael J. Caterina · Nature Neuroscience · 2008 · 319 citations

, , +16

1–5 of 306

Authors

979

  1. JB
    Johannes Bufler

    Medizinische Hochschule Hannover, Germany

    7 publications · 192 citations

    7

    h-index

  2. RG
    Rashid Giniatullin

    University of Eastern Finland, Finland

    5 publications · 219 citations

    5

    h-index

  3. AN
    Andrea Nistri

    Scuola Internazionale Superiore di Studi Avanzati, Italy

    5 publications · 189 citations

    5

    h-index

  4. RL
    Rodney L. Parsons

    University of Vermont, United States

    5 publications · 173 citations

    5

    h-index

  5. JK
    J.S. Kastrup

    University of Copenhagen, Denmark

    4 publications · 115 citations

    4

    h-index

1–5 of 979

Institutions

309

  1. University College London

    London, United Kingdom

    11 h-index

    31 publications

    2.4K citations

  2. Vollum Institute

    Portland, United States

    9 h-index

    18 publications

    2.9K citations

  3. Oregon Health & Science University

    Portland, United States

    9 h-index

    16 publications

    1.7K citations

  4. National Institutes of Health

    Bethesda, United States

    8 h-index

    24 publications

    1.1K citations

  5. University of Copenhagen

    Copenhagen, Denmark

    6 h-index

    22 publications

    798 citations

  6. Scuola Internazionale Superiore di Studi Avanzati

    Trieste, Italy

    6 h-index

    23 publications

    848 citations

  7. Massachusetts General Hospital

    Boston, United States

    6 h-index

    9 publications

    376 citations

  8. Johns Hopkins University

    Baltimore, United States

    6 h-index

    13 publications

    1.4K citations

1–8 of 309

Venues

  1. The Journal of Physiology

    46 publications · 3.4K citations

    35

    h-index

  2. Journal of Neuroscience

    24 publications · 3K citations

    24

    h-index

  3. Journal of Biological Chemistry

    JBC · 23 publications · 1.9K citations

    21

    h-index

  4. Molecular Pharmacology

    23 publications · 980 citations

    20

    h-index

  5. British Journal of Pharmacology

    BJP · 21 publications · 819 citations

    17

    h-index

1–5