Concepedia

Denaturation

Denaturation is a biochemical process in which an enzyme loses its native three-dimensional structure due to disruption of non-covalent interactions and disulfide bonds, leading to the loss of catalytic activity without cleavage of peptide bonds.

6.2K

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352.4K

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18.6K

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3.3K

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Publications per year

2017–2026

578

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Publications

6.2K

Some Factors in the Interpretation of Protein Denaturation

W. Kauzmann · Advances in protein chemistry · 1959 · 4.9K citations

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Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature

Julius Marmur, Paul Doty · Journal of Molecular Biology · 1962 · 4.1K citations

, , +16

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

Ellson Y. Chen, Peter H. Seeburg · DNA · 1985 · 2.5K citations

, , +14

CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR

M. Kunitz · The Journal of General Physiology · 1947 · 2.4K citations · Full text

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Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures.

Heinz L. Sänger, Günther Klotz, D. Riesner et al. · Proceedings of the National Academy of Sciences · 1976 · 2.4K citations · Full text

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1–5 of 6.2K

Authors

18.6K

  1. JW
    Jeffery W. Kelly

    Scripps Research Institute, United States

    19 publications · 2.9K citations

    19

    h-index

  2. GG
    Giuseppe Graziano

    University of Sannio, Italy

    24 publications · 801 citations

    18

    h-index

  3. JM
    Julian M. Sturtevant

    Yale University, United States

    19 publications · 1.4K citations

    18

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  4. PL
    Peter L. Privalov

    Johns Hopkins University, United States

    17 publications · 2.2K citations

    16

    h-index

  5. RJ
    Rainer Jaenicke

    University of Regensburg, Germany

    17 publications · 1K citations

    16

    h-index

1–5 of 18.6K

Institutions

3.3K

  1. Centre National de la Recherche Scientifique

    Paris, France

    47 h-index

    447 publications

    29K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    42 h-index

    150 publications

    15.3K citations

  3. Johns Hopkins University

    Baltimore, United States

    37 h-index

    155 publications

    10.9K citations

  4. National Institutes of Health

    Bethesda, United States

    34 h-index

    187 publications

    13.7K citations

  5. Harvard University

    Cambridge, United States

    34 h-index

    137 publications

    20.9K citations

  6. University of Wisconsin–Madison

    Madison, United States

    31 h-index

    132 publications

    9.8K citations

  7. The University of Tokyo

    Tokyo, Japan

    31 h-index

    150 publications

    20.4K citations

  8. Kyoto University

    Kyoto, Japan

    30 h-index

    168 publications

    6K citations

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Venues

  1. Biochemistry

    516 publications · 31.3K citations

    88

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  2. Journal of Biological Chemistry

    JBC · 349 publications · 25.5K citations

    83

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  3. Proceedings of the National Academy of Sciences

    PNAS · 159 publications · 23.5K citations

    79

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  4. Journal of the American Chemical Society

    JACS · 128 publications · 11K citations

    66

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  5. Journal of Agricultural and Food Chemistry

    149 publications · 10.8K citations

    63

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