Concepedia

Cyclosome Regulation

Cyclosome Regulation is a molecular control mechanism that governs the activation and substrate specificity of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase, to ensure precise temporal degradation of cell-cycle regulatory proteins during mitotic progression and exit.

214

Publications

15.5K

Citations

970

Authors

346

Institutions

Publications per year

2017–2026

34

Parents

Publications

214

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Valery Sudakin, Gordon K. Chan, Tim J. Yen · The Journal of Cell Biology · 2001 · 911 citations · Full text

, , +17

Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1

Edgar R. Kramer, Nadja Scheuringer, Alexandre V. Podtelejnikov et al. · Molecular Biology of the Cell · 2000 · 461 citations

, , +17

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

Catherine Lindon, Jonathon Pines · The Journal of Cell Biology · 2004 · 351 citations · Full text

, , +15

Checkpoint Protein BubR1 Acts Synergistically with Mad2 to Inhibit Anaphase-promoting Complex

Guowei Fang · Molecular Biology of the Cell · 2002 · 328 citations · Full text

, , +17

Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

Franz Herzog, Ivana Primorac, Prakash Dube et al. · Science · 2009 · 253 citations · Full text

, , +17

1–5 of 214

Authors

970

  1. AH
    Avram Hershko

    Technion – Israel Institute of Technology, Israel

    17 publications · 1.2K citations

    16

    h-index

  2. DS
    Danielle Sitry-Shevah

    Technion – Israel Institute of Technology, Israel

    8 publications · 357 citations

    8

    h-index

  3. HY
    Hiroyuki Yamano

    University College London, United Kingdom

    8 publications · 389 citations

    8

    h-index

  4. SM
    Shirly Miniowitz-Shemtov

    Technion – Israel Institute of Technology, Israel

    8 publications · 359 citations

    8

    h-index

  5. MB
    Michael Brandeis

    Hebrew University of Jerusalem, Israel

    7 publications · 387 citations

    7

    h-index

1–5 of 970

Institutions

346

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    44 publications

    3.7K citations

  2. Technion – Israel Institute of Technology

    Haifa, Israel

    15 h-index

    73 publications

    4.7K citations

  3. Stanford University

    Stanford, United States

    10 h-index

    35 publications

    4.3K citations

  4. Harvard University

    Cambridge, United States

    9 h-index

    25 publications

    2.3K citations

  5. University of California, San Francisco

    San Francisco, United States

    8 h-index

    26 publications

    2.4K citations

  6. University of Cambridge

    Cambridge, United Kingdom

    7 h-index

    16 publications

    1.5K citations

  7. Hebrew University of Jerusalem

    Jerusalem, Israel

    7 h-index

    27 publications

    1.1K citations

  8. Research Institute of Molecular Pathology

    Vienna, Austria

    7 h-index

    33 publications

    6.2K citations

1–8 of 346

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 34 publications · 2.9K citations

    26

    h-index

  2. Journal of Biological Chemistry

    JBC · 16 publications · 727 citations

    15

    h-index

  3. Cell Cycle

    11 publications · 476 citations

    11

    h-index

  4. Molecular Biology of the Cell

    MBC · 10 publications · 1.2K citations

    10

    h-index

  5. Molecular and Cellular Biology

    MCB · 10 publications · 671 citations

    10

    h-index

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