Concepedia

Cyclopropene Ligation

Cyclopropene Ligation is a bioorthogonal reaction method in which a cyclopropene functions as a strained dienophile in an inverse electron-demand Diels–Alder cycloaddition with a tetrazine, enabling site-specific covalent labeling of biomolecules under physiological conditions.

24

Publications

1.4K

Citations

77

Authors

22

Institutions

Publications per year

2017–2026

10

Parents

Publications

24

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine– <i>trans-</i> Cyclooctene Ligation

Michael T. Taylor, Melissa L. Blackman, Olga Dmitrenko et al. · Journal of the American Chemical Society · 2011 · 346 citations

, , +15

Constructing New Bioorthogonal Reagents and Reactions

R. David Row, Jennifer A. Prescher · Accounts of Chemical Research · 2018 · 177 citations

, , +8

A Bioorthogonal Ligation of Cyclopropenones Mediated by Triarylphosphines

Hui‐Wen Shih, Jennifer A. Prescher · Journal of the American Chemical Society · 2015 · 91 citations

, , +7

Cyclopropenones for Metabolic Targeting and Sequential Bioorthogonal Labeling

R. David Row, Hui‐Wen Shih, Austin T. Alexander et al. · Journal of the American Chemical Society · 2017 · 84 citations

, , +13

Platinum(II)-Catalyzed 1,6-Diene Cycloisomerizations:  Turnover in the Absence of β-Hydride Elimination

William D. Kerber, Jeong Hwan Koh, Michel R. Gagné · Organic Letters · 2004 · 69 citations

, , +10

1–5 of 24

Authors

77

  1. JA
    Jennifer A. Prescher

    University of California, Irvine, United States

    5 publications · 382 citations

    5

    h-index

  2. ST
    Scott T. Laughlin

    University of California, Berkeley, United States

    3 publications · 126 citations

    3

    h-index

  3. RD
    R. David Row

    University of California, Irvine, United States

    3 publications · 279 citations

    3

    h-index

  4. TJ
    Ting Jiang

    Lanzhou Institute of Chemical Physics, China

    3 publications · 126 citations

    3

    h-index

  5. PK
    Pratik Kumar

    Stony Brook University, United States

    3 publications · 126 citations

    3

    h-index

1–5 of 77

Institutions

22

  1. University of California, Irvine

    Irvine, United States

    5 h-index

    11 publications

    848 citations

  2. Stony Brook University

    Stony Brook, United States

    3 h-index

    19 publications

    800 citations

  3. The University of Texas at Austin

    Austin, United States

    1 h-index

    1 publications

    47 citations

  4. Oregon State University

    Corvallis, United States

    1 h-index

    5 publications

    420 citations

  5. Wuhan University

    Wuhan, China

    1 h-index

    7 publications

    161 citations

  6. University of Ottawa

    Ottawa, Canada

    1 h-index

    3 publications

    57 citations

  7. UiT The Arctic University of Norway

    Tromsø, Norway

    1 h-index

    1 publications

    47 citations

  8. Laboratoire de Chimie Organique

    Paris, France

    1 h-index

    3 publications

    120 citations

1–8 of 22

Venues

  1. Tetrahedron Letters

    5 publications · 187 citations

    5

    h-index

  2. Organic Letters

    OL · 4 publications · 178 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 3 publications · 521 citations

    3

    h-index

  4. The Journal of Organic Chemistry

    JOC · 2 publications · 47 citations

    2

    h-index

  5. Journal of Molecular Structure

    1 publications · 47 citations

    1

    h-index

1–5