Concepedia

Covalent Intermediate Formation

Covalent Intermediate Formation is a mechanistic process in covalent catalysis wherein a transient covalent bond forms between a catalyst and a substrate, distinguishing it from non-covalent catalytic mechanisms by enabling bond reorganization through shared electron pair interactions.

254

Publications

13.4K

Citations

964

Authors

324

Institutions

Publications per year

2017–2026

26

Parents

Publications

254

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

David J. Vocadlo, G.J. Davies, Roger A. Laine et al. · Nature · 2001 · 634 citations · Full text

, , +14

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine.

Daniel V. Santi, Anne M. Norment, Charles Garrett · Proceedings of the National Academy of Sciences · 1984 · 522 citations · Full text

, , +17

Inhibition of pancreatic lipase <i>in vitro</i> by the covalent inhibitor tetrahydrolipstatin

Paul Hadváry, Hans Lengsfeld, H Wolfer · Biochemical Journal · 1988 · 338 citations

, , +16

Peptide synthesis using unprotected peptides through orthogonal coupling methods.

James P. Tam, Yi‐An Lu, Chuan‐Fa Liu · Proceedings of the National Academy of Sciences · 1995 · 252 citations

, , +13

<i>Trypanosoma c</i><i>ruzi</i> Trans-sialidase Operates through a Covalent Sialyl−Enzyme Intermediate:  Tyrosine Is the Catalytic Nucleophile

Andrew G. Watts, Iben Damager, Maria L. Amaya et al. · Journal of the American Chemical Society · 2003 · 209 citations

, , +17

1–5 of 254

Authors

964

  1. SG
    Stephen G. Withers

    University of British Columbia, Canada

    14 publications · 1.8K citations

    13

    h-index

  2. GD
    G.J. Davies

    University of York, United Kingdom

    5 publications · 844 citations

    5

    h-index

  3. AG
    Andrew G. Watts

    University of Bath, United Kingdom

    4 publications · 479 citations

    4

    h-index

  4. DV
    Daniel V. Santi

    University of California, San Francisco, United States

    4 publications · 589 citations

    4

    h-index

  5. PA
    Perry A. Frey

    University of Wisconsin–Madison, United States

    4 publications · 103 citations

    4

    h-index

1–5 of 964

Institutions

324

  1. University of British Columbia

    Vancouver, Canada

    14 h-index

    58 publications

    7.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    43 publications

    1.9K citations

  3. University of Wisconsin–Madison

    Madison, United States

    8 h-index

    15 publications

    549 citations

  4. University of Toronto

    Toronto, Canada

    8 h-index

    17 publications

    917 citations

  5. University of California, San Francisco

    San Francisco, United States

    6 h-index

    18 publications

    2.2K citations

  6. University of York

    York, United Kingdom

    6 h-index

    23 publications

    1.8K citations

  7. University of California, Berkeley

    Berkeley, United States

    5 h-index

    15 publications

    572 citations

  8. University of Groningen

    Groningen, The Netherlands

    5 h-index

    29 publications

    2K citations

1–8 of 324

Venues

  1. Biochemistry

    37 publications · 1.7K citations

    28

    h-index

  2. Journal of Biological Chemistry

    JBC · 34 publications · 2K citations

    25

    h-index

  3. Journal of the American Chemical Society

    JACS · 25 publications · 1.3K citations

    21

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.5K citations

    14

    h-index

  5. Biochemical Journal

    BJ · 10 publications · 666 citations

    10

    h-index

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