Concepedia

Cope Elimination

Cope Elimination is a thermal elimination reaction, specifically a syn-elimination process, in which a tertiary amine oxide undergoes pyrolysis to yield an alkene, a secondary amine, and water, distinguished from other elimination reactions by its concerted, intramolecular mechanism via a cyclic transition state.

61

Publications

2.1K

Citations

176

Authors

62

Institutions

Publications per year

2017–2026

7

Parents

Publications

61

<b>Room Temperature Wolff-Kishner Reduction and Cope Elimination Reactions</b>

Donald J. Cram, M. R. V. Sahyun · Journal of the American Chemical Society · 1962 · 160 citations

, , +6

Cope Elimination:  Elucidation of Solvent Effects from QM/MM Simulations

Orlando Acevedo, William L. Jorgensen · Journal of the American Chemical Society · 2006 · 85 citations

, , +17

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Roger J. Griffin, Andrew Henderson, Nicola J. Curtin et al. · Journal of the American Chemical Society · 2006 · 81 citations

, , +7

Reverse Cope Elimination of Hydroxylamines and Alkenes or Alkynes: Theoretical Investigation of Tether Length and Substituent Effects

Elizabeth H. Krenske, Edwin C. Davison, Ian T. Forbes et al. · Journal of the American Chemical Society · 2012 · 79 citations · Full text

, , +11

Synthesis of Isoxazoline/Cyclic Nitrone-Featured Methylenes Using Unsaturated Ketoximes: A Dual Role of TEMPO

Fei Chen, Xiu‐Long Yang, Zhiwei Wu et al. · The Journal of Organic Chemistry · 2016 · 76 citations

, , +13

1–5 of 61

Authors

176

  1. DW
    David W. Knight

    Cardiff University, United Kingdom

    4 publications · 100 citations

    4

    h-index

  2. IA
    Ian A. O’Neil

    University of Liverpool, United Kingdom

    3 publications · 36 citations

    3

    h-index

  3. YL
    Yves Langlois

    Centre National de la Recherche Scientifique, France

    3 publications · 55 citations

    3

    h-index

  4. EC
    Engelbert Ciganek

    DuPont (United States), United States

    3 publications · 178 citations

    3

    h-index

  5. SR
    Steven R. Thornton

    University of Geneva, Switzerland

    2 publications · 59 citations

    2

    h-index

1–5 of 176

Institutions

62

  1. Cardiff University

    Cardiff, United Kingdom

    4 h-index

    8 publications

    190 citations

  2. University of Ottawa

    Ottawa, Canada

    3 h-index

    12 publications

    716 citations

  3. Tohoku University

    Sendai, Japan

    2 h-index

    6 publications

    183 citations

  4. University of Geneva

    Geneva, Switzerland

    2 h-index

    4 publications

    94 citations

  5. University of Nottingham

    Nottingham, United Kingdom

    2 h-index

    3 publications

    71 citations

  6. Institut de Chimie des Substances Naturelles

    Gif-sur-Yvette, France

    2 h-index

    8 publications

    107 citations

  7. University of Liverpool

    Liverpool, United Kingdom

    2 h-index

    6 publications

    70 citations

  8. Laboratoire de Synthèse Organique

    Palaiseau, France

    1 h-index

    2 publications

    64 citations

1–8 of 62

Venues

  1. Tetrahedron Letters

    10 publications · 175 citations

    10

    h-index

  2. Journal of the American Chemical Society

    JACS · 7 publications · 525 citations

    7

    h-index

  3. Chemical Communications

    ChemComm · 6 publications · 131 citations

    6

    h-index

  4. The Journal of Organic Chemistry

    JOC · 5 publications · 282 citations

    5

    h-index

  5. Organic & Biomolecular Chemistry

    3 publications · 149 citations

    3

    h-index

1–5