Concepedia

Context-specific Genetic Interactions

Context-Specific Genetic Interactions is a genetic interaction phenomenon defined as the dependence of synthetic lethality on particular cellular or molecular contexts, distinguishing it from constitutive genetic interactions by its conditional manifestation under specific genetic, epigenetic, or environmental backgrounds.

24

Publications

1.4K

Citations

227

Authors

91

Institutions

Publications per year

2017–2026

10

Parents

Publications

24

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Glenn S. Cowley, Barbara A. Weir, Francisca Vázquez et al. · Scientific Data · 2014 · 413 citations · Full text

, , +13

Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells

Casey E. Romanoski, Sangderk Lee, Michelle Kim et al. · The American Journal of Human Genetics · 2010 · 115 citations · Full text

, , +15

Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor

Alexis Lalouette, Ann M. Lohof, Constantino Sotelo et al. · Neuroscience · 2001 · 106 citations

, , +9

Genetic interactions underlying flower color patterns in Antirrhinum majus.

Jorge Cury de Almeida, R. Carpenter, Timothy P. Robbins et al. · Genes & Development · 1989 · 102 citations · Full text

, , +17

Flexibility in a Gene Network Affecting a Simple Behavior in Drosophila melanogaster

Bruno van Swinderen, Ralph J. Greenspan · Genetics · 2005 · 101 citations · Full text

, , +13

1–5 of 24

Authors

227

  1. GS
    Glenn S. Cowley

    Broad Institute, United States

    1 publications · 413 citations

    1

    h-index

  2. SK
    Sameera Kongara

    Rutgers, The State University of New Jersey, United States

    1 publications · 40 citations

    1

    h-index

  3. CC
    Călin C. Guet

    Institute of Science and Technology Austria, Austria

    1 publications · 29 citations

    1

    h-index

  4. JP
    Junmin Peng

    St. Jude Children's Research Hospital, United States

    1 publications · 30 citations

    1

    h-index

  5. NN
    Nikhil N. Mutyal

    Northwestern University, United States

    1 publications · 29 citations

    1

    h-index

1–5 of 227

Institutions

91

  1. Stanford University

    Stanford, United States

    3 h-index

    8 publications

    305 citations

  2. German Cancer Research Center

    Heidelberg, Germany

    2 h-index

    25 publications

    608 citations

  3. University of California, Berkeley

    Berkeley, United States

    2 h-index

    3 publications

    151 citations

  4. UCSF Helen Diller Family Comprehensive Cancer Center

    San Francisco, United States

    2 h-index

    6 publications

    246 citations

  5. Sorbonne Université

    Paris, France

    2 h-index

    6 publications

    216 citations

  6. Heidelberg University

    Heidelberg, Germany

    2 h-index

    19 publications

    488 citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    4 publications

    79 citations

  8. SIB Swiss Institute of Bioinformatics

    Lausanne, Switzerland

    2 h-index

    3 publications

    80 citations

1–8 of 91

Venues

  1. Nature Communications

    3 publications · 92 citations

    3

    h-index

  2. 2

    h-index

  3. eLife

    1 publications · 29 citations

    1

    h-index

  4. Journal of Biotechnology

    1 publications · 27 citations

    1

    h-index

  5. Child Development

    1 publications · 37 citations

    1

    h-index

1–5