Concepedia

Conservative Substitution

Conservative Substitution is a bioisosteric replacement strategy in medicinal chemistry wherein a substituent or functional group is replaced with another that exhibits similar physicochemical properties, such as size, polarity, or electronic characteristics, thereby preserving the overall biological activity of the parent compound.

124

Publications

7.8K

Citations

557

Authors

210

Institutions

Publications per year

2017–2026

8

Parents

Publications

124

Evolution of the Structure of Ferredoxin Based on Living Relics of Primitive Amino Acid Sequences

Richard V. Eck, M. O. Dayhoff · Science · 1966 · 486 citations

, , +17

Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic <i>Methanococcus</i> species

Paul Haney, Jonathan H. Badger, Gerald L. Buldak et al. · Proceedings of the National Academy of Sciences · 1999 · 322 citations · Full text

, , +14

Genetic analysis of the human cytochrome P450 CYP2C9 locus

Michael J. Stubbins, Lorna W. Harries, Gillian Smith et al. · Pharmacogenetics · 1996 · 303 citations

, , +14

Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β Ligands

Michael S. Malamas, Eric S. Manas, Robert McDevitt et al. · Journal of Medicinal Chemistry · 2004 · 260 citations · Full text

, , +17

Analysis of protein conformational characteristics related to thermostability

Enrique Querol, Josep A. Pérez-Pons, Ángel Mozo-Villarias · Protein Engineering Design and Selection · 1996 · 250 citations

, , +17

1–5 of 124

Authors

557

  1. EG
    Esme GROSS

    Royal Hallamshire Hospital, United Kingdom

    2 publications · 62 citations

    2

    h-index

  2. MP
    Maria Pellegrini

    Dartmouth College, United States

    2 publications · 40 citations

    2

    h-index

  3. PR
    Paul R. Crocker

    University of Dundee, United Kingdom

    2 publications · 87 citations

    2

    h-index

  4. MS
    M. S. Lennard

    Royal Hallamshire Hospital, United Kingdom

    2 publications · 62 citations

    2

    h-index

  5. EH
    Emma Hilton

    University of Manchester, United Kingdom

    2 publications · 62 citations

    2

    h-index

1–5 of 557

Institutions

210

  1. University of Wisconsin–Madison

    Madison, United States

    4 h-index

    15 publications

    736 citations

  2. University of Dundee

    Dundee, United Kingdom

    4 h-index

    9 publications

    1.5K citations

  3. Washington University in St. Louis

    St Louis, United States

    3 h-index

    9 publications

    797 citations

  4. University of Oxford

    Oxford, United Kingdom

    3 h-index

    3 publications

    107 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    7 publications

    155 citations

  6. University of Manchester

    Manchester, United Kingdom

    3 h-index

    8 publications

    431 citations

  7. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    3 h-index

    17 publications

    1.2K citations

  8. John Radcliffe Hospital

    Oxford, United Kingdom

    3 h-index

    10 publications

    444 citations

1–8 of 210

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 1.1K citations

    16

    h-index

  2. Biochemical Journal

    BJ · 8 publications · 389 citations

    8

    h-index

  3. Molecular and Cellular Biology

    MCB · 6 publications · 203 citations

    6

    h-index

  4. The Journal of Immunology

    JI · 6 publications · 261 citations

    6

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 826 citations

    6

    h-index

1–5