Concepedia

Conditional Lethality

Conditional lethality is a biocontainment strategy that belongs to the class of genetic confinement methods, distinguished by its reliance on engineered dependencies or environmental conditions that selectively induce cell death in the absence of specific exogenous factors, thereby preventing the survival of genetically modified organisms outside controlled settings.

121

Publications

7.7K

Citations

486

Authors

164

Institutions

Publications per year

2017–2026

16

Parents

Publications

121

Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient <i>GluR-B</i> Allele in Mice

R. Brusa, Frank Zimmermann, Duk‐Su Koh et al. · Science · 1995 · 596 citations

, , +17

COLD-SENSITIVE CELL-DIVISION-CYCLE MUTANTS OF YEAST: ISOLATION, PROPERTIES, AND PSEUDOREVERSION STUDIES

Don Moir, Sue Stewart, Barbara C Osmond et al. · Genetics · 1982 · 371 citations

, , +17

Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.

Hannah Nelson, Nathan Nelson · Proceedings of the National Academy of Sciences · 1990 · 322 citations

, , +17

Conditional Lethality of <i>recA</i> and <i>recB</i> Derivatives of a Strain of <i>Escherichia coli</i> K-12 with a Temperature-Sensitive Deoxyribonucleic Acid Polymerase I

Marilyn Monk, James Kinross · Journal of Bacteriology · 1972 · 270 citations · Full text

, , +12

Overproduction of the Lon protease triggers inhibition of translation in <i>Escherichia coli</i>: involvement of the <i>yefM‐yoeB</i> toxin‐antitoxin system

Susanne K. Christensen, G. Maenhaut-Michel, Natacha Mine et al. · Molecular Microbiology · 2004 · 232 citations · Full text

, , +17

1–5 of 121

Authors

486

  1. AM
    Alfred M. Handler

    Center for Medical, Agricultural and Veterinary Entomology, United States

    4 publications · 213 citations

    4

    h-index

  2. DB
    David Botstein

    Massachusetts Institute of Technology, United States

    4 publications · 483 citations

    4

    h-index

  3. MF
    Marc F. Schetelig

    Justus-Liebig-Universität Gießen, Germany

    4 publications · 363 citations

    4

    h-index

  4. PH
    Philip Hieter

    Johns Hopkins University, United States

    3 publications · 136 citations

    3

    h-index

  5. LA
    Luke Alphey

    University of Oxford, United Kingdom

    2 publications · 34 citations

    2

    h-index

1–5 of 486

Institutions

164

  1. Center for Medical, Agricultural and Veterinary Entomology

    Gainesville, United States

    5 h-index

    10 publications

    604 citations

  2. Johns Hopkins University

    Baltimore, United States

    4 h-index

    12 publications

    551 citations

  3. The University of Tokyo

    Tokyo, Japan

    4 h-index

    8 publications

    305 citations

  4. Justus-Liebig-Universität Gießen

    Giessen, Germany

    3 h-index

    3 publications

    274 citations

  5. University of British Columbia

    Vancouver, Canada

    3 h-index

    15 publications

    656 citations

  6. Johns Hopkins Medicine

    Baltimore, United States

    3 h-index

    7 publications

    341 citations

  7. University of Alberta

    Edmonton, Canada

    3 h-index

    11 publications

    934 citations

  8. University of Georgia

    Athens, United States

    3 h-index

    9 publications

    668 citations

1–8 of 164

Venues

  1. Genetics

    14 publications · 1.1K citations

    12

    h-index

  2. Journal of Bacteriology

    JB · 12 publications · 1.1K citations

    12

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 795 citations

    11

    h-index

  4. PLoS ONE

    5 publications · 186 citations

    5

    h-index

  5. Molecular and Cellular Biology

    MCB · 4 publications · 255 citations

    4

    h-index

1–5