Concepedia

Computational Mutagenesis

Computational Mutagenesis is a computational method that systematically predicts the effects of amino acid substitutions on protein structure and function by in silico modeling and simulation, distinguishing it from experimental mutagenesis through its reliance on theoretical and algorithmic approaches to explore sequence-function relationships.

172

Publications

13.5K

Citations

733

Authors

300

Institutions

Publications per year

2017–2026

51

Parents

Publications

172

SIFT: predicting amino acid changes that affect protein function

P.C. Ng · Nucleic Acids Research · 2003 · 6.9K citations · Full text

, , +17

Benchmark Data Set for in Silico Prediction of Ames Mutagenicity

Katja Hansen, Sebastian Mika, Timon Schroeter et al. · Journal of Chemical Information and Modeling · 2009 · 367 citations · Full text

, , +15

Massively parallel single-amino-acid mutagenesis

Jacob O. Kitzman, Lea M. Starita, Russell S. Lo et al. · Nature Methods · 2015 · 194 citations · Full text

, , +5

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

Paul D. Adams, Isaiah T. Arkin, Donald M. Engelman et al. · Nature Structural & Molecular Biology · 1995 · 194 citations

, , +11

Quantification of biases in predictions of protein stability changes upon mutations

Fabrizio Pucci, Katrien V. Bernaerts, Jean Marc Kwasigroch et al. · Bioinformatics · 2018 · 180 citations · Full text

, , +14

1–5 of 172

Authors

733

  1. MJ
    Maria J. Ramos

    Universidade do Porto, Portugal

    6 publications · 240 citations

    6

    h-index

  2. MM
    Majid Masso

    George Mason University, United States

    6 publications · 387 citations

    6

    h-index

  3. II
    Iosif I. Vaisman

    George Mason University, United States

    6 publications · 387 citations

    6

    h-index

  4. IS
    Irina S. Moreira

    Universidade do Porto, Portugal

    6 publications · 271 citations

    6

    h-index

  5. PA
    Pedro Alexandrino Fernandes

    Universidade do Porto, Portugal

    6 publications · 240 citations

    6

    h-index

1–5 of 733

Institutions

300

  1. Universidade do Porto

    Porto, Portugal

    8 h-index

    25 publications

    1.1K citations

  2. Rede de Química e Tecnologia

    Porto, Portugal

    8 h-index

    25 publications

    1.1K citations

  3. George Mason University

    Fairfax, United States

    7 h-index

    15 publications

    825 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    31 publications

    900 citations

  5. University of Cambridge

    Cambridge, United Kingdom

    6 h-index

    19 publications

    828 citations

  6. Stanford University

    Stanford, United States

    5 h-index

    20 publications

    592 citations

  7. National Institutes of Health

    Bethesda, United States

    4 h-index

    13 publications

    420 citations

  8. University of California, San Francisco

    San Francisco, United States

    4 h-index

    6 publications

    273 citations

1–8 of 300

Venues

  1. Bioinformatics

    10 publications · 660 citations

    10

    h-index

  2. PLoS ONE

    9 publications · 295 citations

    9

    h-index

  3. Journal of Biological Chemistry

    JBC · 8 publications · 379 citations

    8

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 7 publications · 549 citations

    7

    h-index

  5. Proteins Structure Function and Bioinformatics

    7 publications · 243 citations

    7

    h-index

1–5