Concepedia

Computational Directed Evolution

Computational Directed Evolution is a computational method that simulates iterative rounds of mutation, selection, and recombination in silico to optimize enzyme function by mimicking the principles of natural evolution within a designed sequence space.

82

Publications

5K

Citations

398

Authors

174

Institutions

Publications per year

2017–2026

37

Parents

Publications

82

Low-N protein engineering with data-efficient deep learning

Surojit Biswas, Grigory Khimulya, Ethan C. Alley et al. · Nature Methods · 2021 · 417 citations

, , +14

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.

M. Cecilia Orencia, Jun Sik Yoon, Jon E. Ness et al. · Nature Structural Biology · 2001 · 243 citations

, , +16

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

David Bednář, Koen Beerens, Eva Šebestová et al. · PLoS Computational Biology · 2015 · 205 citations · Full text

, , +17

Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution

Olga Khersonsky, Daniela Röthlisberger, Andrew M. Wollacott et al. · Journal of Molecular Biology · 2011 · 182 citations · Full text

, , +14

Computational method to reduce the search space for directed protein evolution

Christopher A. Voigt, Stephen L. Mayo, Frances H. Arnold et al. · Proceedings of the National Academy of Sciences · 2001 · 179 citations · Full text

, , +16

1–5 of 82

Authors

398

  1. DB
    David Baker

    University of Washington, United States

    6 publications · 663 citations

    5

    h-index

  2. US
    Ulrich Schwaneberg

    RWTH Aachen University, Germany

    5 publications · 372 citations

    5

    h-index

  3. FH
    Frances H. Arnold

    California Institute of Technology, United States

    4 publications · 335 citations

    4

    h-index

  4. MD
    Mehdi D. Davari

    RWTH Aachen University, Germany

    4 publications · 219 citations

    4

    h-index

  5. DH
    Donald Hilvert

    ETH Zurich, Switzerland

    3 publications · 140 citations

    3

    h-index

1–5 of 398

Institutions

174

  1. University of Washington

    Seattle, United States

    5 h-index

    18 publications

    2.1K citations

  2. Weizmann Institute of Science

    Rehovot, Israel

    4 h-index

    10 publications

    1.4K citations

  3. RWTH Aachen University

    Aachen, Germany

    4 h-index

    15 publications

    801 citations

  4. ETH Zurich

    Zurich, Switzerland

    4 h-index

    13 publications

    730 citations

  5. DWI – Leibniz Institute for Interactive Materials

    Aachen, Germany

    3 h-index

    7 publications

    411 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    11 publications

    1.9K citations

  7. California Institute of Technology

    Pasadena, United States

    3 h-index

    17 publications

    1.5K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    6 publications

    1.3K citations

1–8 of 174

Venues

  1. Journal of Molecular Biology

    JMB · 5 publications · 471 citations

    5

    h-index

  2. ACS Catalysis

    4 publications · 249 citations

    4

    h-index

  3. Journal of Biological Chemistry

    JBC · 4 publications · 157 citations

    4

    h-index

  4. Methods in molecular biology

    Book series · 3 publications · 62 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 218 citations

    2

    h-index

1–5