Concepedia

Complexity-reduced Libraries

Complexity-Reduced Libraries is a library construction strategy that belongs to the class of molecular screening libraries, distinguished by its deliberate reduction in structural or chemical diversity through designed simplification, combinatorial restriction, or bias toward privileged scaffolds to enhance hit identification efficiency in library deconvolution processes.

10

Publications

376

Citations

63

Authors

30

Institutions

Publications per year

2017–2026

4

Parents

Publications

10

Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning

Nadine Körtel, Cornelia Rücklé, You Zhou et al. · Nucleic Acids Research · 2021 · 115 citations · Full text

, , +11

Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics

Wan F. Lau, Jane M. Withka, David Hepworth et al. · Journal of Computer-Aided Molecular Design · 2011 · 61 citations

, , +15

4-exo-dig and 5-exo-dig Cyclocarbopalladations: an expeditious solution toward molecular complexity?

Christophe Bour, Gaëlle Blond, Bahaâ Salem et al. · Tetrahedron · 2006 · 42 citations

, , +8

“Reagent explosion”: an efficient method to increase library size and diversity

Hugues Bienaymé · Tetrahedron Letters · 1998 · 33 citations

, , +13

MiMiC: a bioinformatic approach for generation of synthetic communities from metagenomes

Neeraj Kumar, Thomas C. A. Hitch, Dirk Haller et al. · Microbial Biotechnology · 2021 · 28 citations · Full text

, , +12

1–5 of 10

Authors

63

  1. CD
    Christoph Dieterich

    Heidelberg University, Germany

    1 publications · 115 citations

    1

    h-index

  2. AM
    Allison M. Porman

    Brown University, United States

    1 publications · 26 citations

    1

    h-index

  3. LN
    Lakshmi Narasimhan

    Pfizer (United States), United States

    1 publications · 61 citations

    1

    h-index

  4. JM
    Jane M. Withka

    Pfizer (United States), United States

    1 publications · 61 citations

    1

    h-index

  5. JH
    Jacob Haase

    Martin Luther University Halle-Wittenberg, Germany

    1 publications · 115 citations

    1

    h-index

1–5 of 63

Institutions

30

  1. RWTH Aachen University

    Aachen, Germany

    2 h-index

    5 publications

    314 citations

  2. Pfizer (United States)

    New York, United States

    1 h-index

    14 publications

    854 citations

  3. University Hospital Heidelberg

    Heidelberg, Germany

    1 h-index

    1 publications

    115 citations

  4. Heidelberg University

    Heidelberg, Germany

    1 h-index

    2 publications

    230 citations

  5. Goethe University Frankfurt

    Frankfurt am Main, Germany

    1 h-index

    3 publications

    345 citations

  6. Southeast University

    Dhaka, Bangladesh

    1 h-index

    1 publications

    14 citations

  7. Southeast University

    Nanjing, China

    1 h-index

    2 publications

    28 citations

  8. Anhui Polytechnic University

    Wuhu, China

    1 h-index

    1 publications

    14 citations

1–8 of 30

Venues

  1. Tetrahedron

    1 publications · 42 citations

    1

    h-index

  2. Nucleic Acids Research

    1 publications · 115 citations

    1

    h-index

  3. RNA

    1 publications · 26 citations

    1

    h-index

  4. Genome Research

    GR · 1 publications · 12 citations

    1

    h-index

  5. Neural Networks

    1 publications · 14 citations

    1

    h-index

1–5