Concepedia

Complement-mediated Synapse Elimination

Complement-Mediated Synapse Elimination is a biological mechanism within synaptic refinement whereby specific synapses are selectively eliminated during neural development through the activation of the complement cascade, which tags weaker synapses for phagocytic removal by microglia.

49

Publications

13.8K

Citations

385

Authors

151

Institutions

Publications per year

2017–2026

31

Parents

Publications

49

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman et al. · Neuron · 2012 · 4.1K citations · Full text

, , +14

The Classical Complement Cascade Mediates CNS Synapse Elimination

Beth Stevens, Nicola J. Allen, Luis E Vazquez et al. · Cell · 2007 · 3.3K citations · Full text

, , +10

A complement–microglial axis drives synapse loss during virus-induced memory impairment

Michael J. Vasek, Charise Garber, Denise Dorsey et al. · Nature · 2016 · 681 citations · Full text

, , +12

Microglia mediate forgetting via complement-dependent synaptic elimination

Chao Wang, Huimin Yue, Zhechun Hu et al. · Science · 2020 · 640 citations

, , +17

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma et al. · Immunity · 2019 · 452 citations · Full text

, , +17

1–5 of 49

Authors

385

  1. BS
    Beth Stevens

    Boston Children's Hospital, United States

    9 publications · 9.1K citations

    9

    h-index

  2. AJ
    Andrea J. Tenner

    University of California, Irvine, United States

    5 publications · 1K citations

    5

    h-index

  3. BA
    Ben A. Barres

    Stanford University, United States

    5 publications · 8K citations

    5

    h-index

  4. JK
    József Kardos

    Eötvös Loránd University, Hungary

    3 publications · 295 citations

    3

    h-index

  5. GT
    György Török

    Institute of Molecular Life Sciences, Hungary

    3 publications · 295 citations

    3

    h-index

1–5 of 385

Institutions

151

  1. Broad Institute

    Cambridge, United States

    8 h-index

    31 publications

    4.9K citations

  2. Boston Children's Hospital

    Boston, United States

    8 h-index

    49 publications

    29.1K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    9 publications

    11.4K citations

  4. Stanford University

    Stanford, United States

    6 h-index

    21 publications

    37K citations

  5. Harvard University

    Cambridge, United States

    6 h-index

    46 publications

    35.8K citations

  6. University of California, Irvine

    Irvine, United States

    5 h-index

    14 publications

    4.1K citations

  7. University of Gothenburg

    Gothenburg, Sweden

    4 h-index

    30 publications

    1.9K citations

  8. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    23 publications

    1.3K citations

1–8 of 151

Venues

  1. Journal of Neuroscience

    3 publications · 635 citations

    3

    h-index

  2. Glia

    3 publications · 105 citations

    3

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 77 citations

    2

    h-index

  4. Journal of Neuroinflammation

    JNI · 2 publications · 434 citations

    2

    h-index

  5. Nature Neuroscience

    2 publications · 455 citations

    2

    h-index

1–5