Concepedia

Complement-mediated Podocyte Injury

Complement-Mediated Podocyte Injury is a pathophysiological mechanism within glomerular disease wherein podocyte damage occurs specifically through the activation and deposition of complement system components, distinguishing it from other forms of podocyte injury driven by immune-complex deposition, metabolic, or mechanical insults.

39

Publications

2.2K

Citations

291

Authors

109

Institutions

Publications per year

2017–2026

16

Parents

Publications

39

Podocytopenia and disease severity in IgA nephropathy

Kevin V. Lemley, Richard Lafayette, Massy Safai et al. · Kidney International · 2002 · 296 citations

, , +13

Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis

Andrea Angeletti, Chiara Cantarelli, Astgik Petrosyan et al. · The Journal of Experimental Medicine · 2020 · 138 citations · Full text

, , +17

DNA damage is a novel response to sublytic complement C5b-9–induced injury in podocytes

Jeffrey W. Pippin, Raghu Durvasula, Arndt T. Petermann et al. · Journal of Clinical Investigation · 2003 · 129 citations

, , +17

DNA damage is a novel response to sublytic complement C5b-9–induced injury in podocytes

Jeffrey W. Pippin, Raghu Durvasula, Arndt T. Petermann et al. · Journal of Clinical Investigation · 2003 · 116 citations · Full text

, , +17

Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro

Zhaohong Chen, Weisong Qin, Caihong Zeng et al. · Kidney International · 2010 · 113 citations · Full text

, , +14

1–5 of 39

Authors

291

  1. GR
    Giuseppe Remuzzi

    Mario Negri Institute for Pharmacological Research, Italy

    4 publications · 249 citations

    4

    h-index

  2. MM
    Marina Morigi

    Mario Negri Institute for Pharmacological Research, Italy

    4 publications · 249 citations

    4

    h-index

  3. DC
    Daniela Corna

    Mario Negri Institute for Pharmacological Research, Italy

    4 publications · 249 citations

    4

    h-index

  4. JM
    Joshua M. Thurman

    University of Colorado Denver, United States

    3 publications · 252 citations

    3

    h-index

  5. ML
    Monica Locatelli

    Mario Negri Institute for Pharmacological Research, Italy

    3 publications · 163 citations

    3

    h-index

1–5 of 291

Institutions

109

  1. Mario Negri Institute for Pharmacological Research

    Milan, Italy

    4 h-index

    39 publications

    2.3K citations

  2. Boston Medical Center

    Boston, United States

    3 h-index

    3 publications

    148 citations

  3. Boston University

    Boston, United States

    3 h-index

    3 publications

    148 citations

  4. Radboud University Nijmegen

    Nijmegen, The Netherlands

    3 h-index

    5 publications

    164 citations

  5. Radboud University Medical Center

    Nijmegen, The Netherlands

    3 h-index

    5 publications

    164 citations

  6. University of Colorado Denver

    Denver, United States

    3 h-index

    3 publications

    252 citations

  7. Washington University in St. Louis

    St Louis, United States

    2 h-index

    2 publications

    83 citations

  8. University of Washington

    Seattle, United States

    2 h-index

    12 publications

    1.5K citations

1–8 of 109

Venues

  1. Kidney International

    4 publications · 516 citations

    4

    h-index

  2. Journal of the American Society of Nephrology

    4 publications · 292 citations

    4

    h-index

  3. JCI Insight

    3 publications · 130 citations

    3

    h-index

  4. Journal of Biological Chemistry

    JBC · 2 publications · 89 citations

    2

    h-index

  5. International Journal of Molecular Sciences

    IJMS · 2 publications · 80 citations

    2

    h-index

1–5