Concepedia

Complement Factor I Deficiency

Complement Factor I Deficiency is a rare inherited disorder of the complement system characterized by impaired regulation of complement activation due to insufficient functional levels of the serine protease Complement Factor I, leading to uncontrolled consumption of complement components and increased susceptibility to recurrent infections and autoimmune manifestations.

85

Publications

5.1K

Citations

448

Authors

221

Institutions

Publications per year

2017–2026

23

Variants

Cfi Deficiency

Parents

Publications

85

Mutations in Complement Factor I Predispose to Development of Atypical Hemolytic Uremic Syndrome

David Kavanagh, Elizabeth J. Kemp, Elizabeth Mayland et al. · Journal of the American Society of Nephrology · 2005 · 476 citations

, , +16

Variation near complement factor I is associated with risk of advanced AMD

Jesen Fagerness, Julian Maller, Benjamin M. Neale et al. · European Journal of Human Genetics · 2008 · 355 citations · Full text

, , +13

Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome

Véronique Frémeaux‐Bacchi · Journal of Medical Genetics · 2004 · 337 citations · Full text

, , +16

Hereditary angio-oedema in Denmark: a nationwide survey

Anette Bygum · British Journal of Dermatology · 2009 · 251 citations

, , +14

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

Frank Bienaimé, Marie‐Agnès Dragon‐Durey, Catherine H. Régnier et al. · Kidney International · 2009 · 189 citations · Full text

, , +12

1–5 of 85

Authors

448

  1. DK
    David Kavanagh

    Newcastle University, United Kingdom

    11 publications · 998 citations

    11

    h-index

  2. VF
    Véronique Frémeaux‐Bacchi

    Hôpital Européen Georges-Pompidou, France

    9 publications · 1.2K citations

    9

    h-index

  3. AM
    Anna M. Blom

    Lund University, Sweden

    8 publications · 541 citations

    8

    h-index

  4. SC
    Sara C. Nilsson

    Lund University, Sweden

    7 publications · 493 citations

    7

    h-index

  5. JP
    John P. Atkinson

    Washington University in St. Louis, United States

    7 publications · 408 citations

    7

    h-index

1–5 of 448

Institutions

221

  1. Lund University

    Lund, Sweden

    11 h-index

    32 publications

    2.1K citations

  2. Newcastle University

    Newcastle upon Tyne, United Kingdom

    11 h-index

    32 publications

    4K citations

  3. Hôpital Européen

    Marseille, France

    9 h-index

    15 publications

    2.8K citations

  4. Inserm

    Paris, France

    8 h-index

    22 publications

    3.3K citations

  5. Washington University in St. Louis

    St Louis, United States

    7 h-index

    27 publications

    1.6K citations

  6. Harvard University

    Cambridge, United States

    7 h-index

    17 publications

    773 citations

  7. Hôpital Européen Georges-Pompidou

    Paris, France

    6 h-index

    9 publications

    1.5K citations

  8. Assistance Publique – Hôpitaux de Paris

    Paris, France

    6 h-index

    13 publications

    2.1K citations

1–8 of 221

Venues

  1. PubMed

    Repository · 5 publications · 263 citations

    5

    h-index

  2. Frontiers in Immunology

    4 publications · 86 citations

    4

    h-index

  3. Scandinavian Journal of Immunology

    4 publications · 161 citations

    4

    h-index

  4. Molecular Immunology

    4 publications · 284 citations

    4

    h-index

  5. Human Molecular Genetics

    3 publications · 189 citations

    3

    h-index

1–5