Concepedia

Combinatorial Perturbation Screening

Combinatorial Perturbation Screening is a genetic interaction mapping method that systematically introduces pairs or higher-order combinations of genetic perturbations to identify epistatic relationships and functional redundancies by analyzing phenotypic deviations from expected additive effects.

12

Publications

1.3K

Citations

102

Authors

41

Institutions

Publications per year

2017–2026

9

Parents

Publications

12

Predicting transcriptional outcomes of novel multigene perturbations with GEARS

Yusuf Roohani, Kexin Huang, Jure Leskovec · Nature Biotechnology · 2023 · 302 citations · Full text

, , +11

Predicting cellular responses to complex perturbations in high‐throughput screens

Mohammad Lotfollahi, Anna Klimovskaia Susmelj, Carlo De Donno et al. · Molecular Systems Biology · 2023 · 269 citations · Full text

, , +14

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM

Alan S.L. Wong, Gigi C.G. Choi, Cheryl H. Cui et al. · Proceedings of the National Academy of Sciences · 2016 · 252 citations · Full text

, , +13

Models from experiments: combinatorial drug perturbations of cancer cells

Sven Nelander, Weiqing Wang, Qing‐Bai She et al. · Molecular Systems Biology · 2008 · 189 citations · Full text

, , +16

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs

Sara Sharifpoor, Dewald van Dyk, Michael Costanzo et al. · Genome Research · 2012 · 75 citations · Full text

, , +17

1–5 of 12

Authors

102

  1. FJ
    Fabian J. Theis

    Helmholtz Zentrum München, Germany

    3 publications · 338 citations

    4

    h-index

  2. ML
    Mohammad Lotfollahi

    Helmholtz Zentrum München, Germany

    3 publications · 338 citations

    3

    h-index

  3. FA
    F. Alexander Wolf

    Helmholtz Zentrum München, Germany

    2 publications · 321 citations

    2

    h-index

  4. AK
    Anna Klimovskaia Susmelj

    Swiss Data Science Center, Switzerland

    2 publications · 321 citations

    2

    h-index

  5. CD
    Carlo De Donno

    Helmholtz Zentrum München, Germany

    2 publications · 321 citations

    2

    h-index

1–5 of 102

Institutions

41

  1. Technical University of Munich

    Munich, Germany

    4 h-index

    10 publications

    1.5K citations

  2. Helmholtz Zentrum München

    Munich, Germany

    4 h-index

    16 publications

    2.2K citations

  3. Broad Institute

    Cambridge, United States

    3 h-index

    15 publications

    1.5K citations

  4. Wellcome Sanger Institute

    Cambridge, United Kingdom

    2 h-index

    4 publications

    859 citations

  5. University of Washington

    Seattle, United States

    2 h-index

    6 publications

    1.4K citations

  6. Harvard University

    Cambridge, United States

    2 h-index

    7 publications

    1.1K citations

  7. Swiss Data Science Center

    Zurich, Switzerland

    2 h-index

    2 publications

    321 citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    10 publications

    1.8K citations

1–8 of 41

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 69 citations

    3

    h-index

  2. Molecular Systems Biology

    2 publications · 458 citations

    2

    h-index

  3. Nature Communications

    1 publications · 67 citations

    1

    h-index

  4. Nature Protocols

    1 publications · 63 citations

    1

    h-index

  5. Genome Research

    GR · 1 publications · 75 citations

    1

    h-index

1–5