Concepedia

Cofactor-dependent Halogenation

Cofactor-Dependent Halogenation is a biochemical process in which halogen atoms are incorporated into organic substrates through enzymatic reactions that require specific cofactors to facilitate the activation and transfer of halogens, distinguishing it from cofactor-independent halogenation mechanisms by its reliance on exogenous molecular cofactors such as flavins, metals, or S-adenosylmethionine for catalytic activity.

34

Publications

2K

Citations

147

Authors

42

Institutions

Publications per year

2017–2026

12

Parents

Publications

34

Robust <i>in vitro</i> activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

Ellen Yeh, Sylvie Garneau‐Tsodikova, Christopher T. Walsh · Proceedings of the National Academy of Sciences · 2005 · 270 citations · Full text

, , +12

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

Megan L. Matthews, Courtney M. Krest, Eric W. Barr et al. · Biochemistry · 2009 · 252 citations · Full text

, , +15

Bacterial dehalogenases: biochemistry, genetics, and biotechnological applications.

Susanne Fetzner, F. Lingens · Microbiological Reviews · 1994 · 185 citations · Full text

, , +16

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

Andrew J. Mitchell, Qin Zhu, Ailiena O. Maggiolo et al. · Nature Chemical Biology · 2016 · 180 citations · Full text

, , +13

Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin–Aspartate Bond

Kateryna Podzelinska, Ryan Latimer, Anupam Bhattacharya et al. · Journal of Molecular Biology · 2010 · 125 citations

, , +10

1–5 of 34

Authors

147

  1. KV
    Karl‐Heinz van Pée

    Technische Universität Dresden, Germany

    4 publications · 133 citations

    4

    h-index

  2. CK
    Carsten Krebs

    Pennsylvania State University, United States

    2 publications · 311 citations

    3

    h-index

  3. JM
    J. Martin Bollinger

    Pennsylvania State University, United States

    2 publications · 311 citations

    3

    h-index

  4. AK
    Amie K. Boal

    Pennsylvania State University, United States

    1 publications · 180 citations

    2

    h-index

  5. JC
    Jared C. Lewis

    University of Chicago, United States

    2 publications · 70 citations

    2

    h-index

1–5 of 147

Institutions

42

  1. Pennsylvania State University

    State College, United States

    4 h-index

    15 publications

    1.9K citations

  2. University of Hohenheim

    Stuttgart, Germany

    4 h-index

    8 publications

    532 citations

  3. University of Manchester

    Manchester, United Kingdom

    3 h-index

    23 publications

    1.1K citations

  4. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    6 publications

    669 citations

  5. Indiana University Bloomington

    Bloomington, United States

    2 h-index

    8 publications

    352 citations

  6. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    10 publications

    676 citations

  7. Harvard University

    Cambridge, United States

    2 h-index

    5 publications

    1.3K citations

  8. Technische Universität Darmstadt

    Darmstadt, Germany

    1 h-index

    3 publications

    78 citations

1–8 of 42

Venues

  1. Tetrahedron Letters

    3 publications · 64 citations

    3

    h-index

  2. ACS Catalysis

    2 publications · 62 citations

    2

    h-index

  3. Journal of Biological Chemistry

    JBC · 2 publications · 119 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 293 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 196 citations

    2

    h-index

1–5