Concepedia

Cofactor-dependent Activation

Cofactor-Dependent Activation is a biochemical mechanism in which an enzyme's catalytic activity is enhanced through the binding of a non-protein cofactor that induces a conformational or functional change essential for the enzyme’s optimal performance.

66

Publications

3.7K

Citations

253

Authors

93

Institutions

Publications per year

2017–2026

5

Parents

Publications

66

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

N L Esmon, Whyte G. Owen, Charles T. Esmon · Journal of Biological Chemistry · 1982 · 707 citations · Full text

, , +14

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

T G Gabig, Denis English, LP Akard et al. · Journal of Biological Chemistry · 1987 · 186 citations · Full text

, , +16

Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID

Joseph D. Fondell, Mohamed Guermah, Sohail Malik et al. · Proceedings of the National Academy of Sciences · 1999 · 166 citations

, , +17

Mechanism of action of the C3b inactivator: Requiremen for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b′)

Shigeharu Nagasawa, Robert M. Stroud · Immunochemistry · 1977 · 152 citations

, , +15

Structural Basis for Activation of Class Ib Ribonucleotide Reductase

Amie K. Boal, Joseph A. Cotruvo, JoAnne Stubbe et al. · Science · 2010 · 148 citations

, , +17

1–5 of 66

Authors

253

  1. RL
    Robert L. Kerby

    University of Wisconsin–Madison, United States

    3 publications · 160 citations

    3

    h-index

  2. GP
    Gary P. Roberts

    University of Wisconsin–Madison, United States

    3 publications · 160 citations

    3

    h-index

  3. TG
    Thomas G. Spiro

    Princeton University, United States

    2 publications · 134 citations

    2

    h-index

  4. HN
    Hironori Niki

    National Institute of Genetics, Japan

    2 publications · 66 citations

    2

    h-index

  5. GB
    Gustav Berggren

    Uppsala University, Sweden

    2 publications · 61 citations

    2

    h-index

1–5 of 253

Institutions

93

  1. University of Wisconsin–Madison

    Madison, United States

    5 h-index

    20 publications

    1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    12 publications

    164 citations

  3. Northwestern University

    Evanston, United States

    3 h-index

    5 publications

    463 citations

  4. Scripps Research Institute

    San Diego, United States

    3 h-index

    6 publications

    368 citations

  5. University of Leeds

    Leeds, United Kingdom

    2 h-index

    5 publications

    99 citations

  6. Oklahoma Medical Research Foundation

    Oklahoma City, United States

    2 h-index

    7 publications

    543 citations

  7. University of Oklahoma Health Sciences Center

    Oklahoma City, United States

    2 h-index

    4 publications

    2.2K citations

  8. Saint Louis University

    St Louis, United States

    2 h-index

    7 publications

    136 citations

1–8 of 93

Venues

  1. Journal of Biological Chemistry

    JBC · 20 publications · 1.7K citations

    18

    h-index

  2. Biochemistry

    8 publications · 262 citations

    8

    h-index

  3. Biochemical Journal

    BJ · 4 publications · 136 citations

    4

    h-index

  4. Chemico-Biological Interactions

    3 publications · 44 citations

    3

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 91 citations

    2

    h-index

1–5