Concepedia

Cofactor Binding Stabilization

Cofactor Binding Stabilization is a thermostability engineering strategy that enhances protein thermal resilience by reinforcing the structural and energetic complementarity between a protein and its cofactor through targeted modifications that reduce dissociation and conformational flexibility at elevated temperatures.

24

Publications

820

Citations

125

Authors

51

Institutions

Publications per year

2017–2026

3

Parents

Publications

24

Crystal Structures of Zinc-free and -bound Heme Domain of Human Inducible Nitric-oxide Synthase

Huiying Li, C.S. Raman, Charles B. Glaser et al. · Journal of Biological Chemistry · 1999 · 236 citations · Full text

, , +15

Evolution of Function in the “Two Dinucleotide Binding Domains” Flavoproteins

Sunil Ojha, Elaine C. Meng, Patricia C. Babbitt · PLoS Computational Biology · 2007 · 66 citations · Full text

, , +17

The Multidomain Thioredoxin-Monothiol Glutaredoxins Represent a Distinct Functional Group

Bastian Hoffmann, Marta A. Uzarska, Carsten Berndt et al. · Antioxidants and Redox Signaling · 2011 · 54 citations

, , +15

Stability and reconstitution of pyruvate oxidase from lactobacillus plantarum: Dissection of the stabilizing effects of coenzyme binding and subunit interaction

Bernhard Risse, Günter Stempfer, Rainer Rudolph et al. · Protein Science · 1992 · 52 citations · Full text

, , +17

Distant residues mediate picomolar binding affinity of a protein cofactor

Yves J. M. Bollen, Adrie H. Westphal, Simon Lindhoud et al. · Nature Communications · 2012 · 40 citations · Full text

, , +17

1–5 of 24

Authors

125

  1. BR
    Bernhard Risse

    University of Regensburg, Germany

    2 publications · 65 citations

    2

    h-index

  2. RJ
    Rainer Jaenicke

    University of Regensburg, Germany

    2 publications · 65 citations

    2

    h-index

  3. WJ
    Willem J. H. van Berkel

    Wageningen University & Research, Netherlands

    2 publications · 50 citations

    2

    h-index

  4. JS
    Javier Sancho

    Universidad de Zaragoza, Spain

    2 publications · 42 citations

    2

    h-index

  5. SL
    Simon Lindhoud

    Wageningen University & Research, Netherlands

    2 publications · 50 citations

    2

    h-index

1–5 of 125

Institutions

51

  1. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    8 publications

    229 citations

  2. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    2 h-index

    4 publications

    130 citations

  3. Wageningen University & Research

    Wageningen, The Netherlands

    2 h-index

    8 publications

    200 citations

  4. University of Michigan

    Ann Arbor, United States

    2 h-index

    7 publications

    219 citations

  5. Universidad de Zaragoza

    Zaragoza, Spain

    2 h-index

    7 publications

    126 citations

  6. University of Regensburg

    Regensburg, Germany

    2 h-index

    6 publications

    195 citations

  7. National Institute of Neurological Disorders and Stroke

    Bethesda, United States

    1 h-index

    2 publications

    34 citations

  8. Philipps University of Marburg

    Marburg, Germany

    1 h-index

    8 publications

    432 citations

1–8 of 51

Venues

  1. Biochemistry

    4 publications · 77 citations

    4

    h-index

  2. Journal of Biological Chemistry

    JBC · 4 publications · 319 citations

    4

    h-index

  3. Protein Science

    PS · 2 publications · 65 citations

    2

    h-index

  4. PLoS ONE

    2 publications · 20 citations

    2

    h-index

  5. 1

    h-index

1–5