Concepedia

Cofactor Binding Site Engineering

Cofactor Binding Site Engineering is a methodological approach within active site engineering that specifically involves the rational modification or design of enzyme binding pockets to enhance or alter the affinity, specificity, or reactivity toward cofactors, thereby optimizing catalytic performance.

5

Publications

266

Citations

22

Authors

17

Institutions

Publications per year

2017–2026

1

Parents

Publications

5

Deep Knot Structure for Construction of Active Site and Cofactor Binding Site of tRNA Modification Enzyme

Osamu Nureki, Kazunori Watanabe, Shuya Fukai et al. · Structure · 2004 · 142 citations · Full text

, , +17

Interaction of Tyr103 and Tyr264 of the Reca Protein with DNA and Nucleotide Cofactors. Fluorescence Study of Engineered Proteins

Katsumi Morimatsu, Toshihiro Horii, Masayuki Takahash · European Journal of Biochemistry · 1995 · 34 citations

, , +15

Mechanism of Action of Flavin-Dependent Halogenases

Rhys Barker, Yuqi Yu, Leonardo De Maria et al. · ACS Catalysis · 2022 · 33 citations · Full text

, , +17

Interaction of Tyr103 and Tyr264 of the Reca Protein with DNA and Nucleotide Cofactors. Fluorescence Study of Engineered Proteins

Katsumi Morimatsu, Toshihiro Horii, Masayuki Takahash · European Journal of Biochemistry · 1995 · 30 citations

, , +15

Inhibition of the Thioredoxin-dependent Activation of the NADP-malate Dehydrogenase and Cofactor Specificity

Isabelle Schepens, Kenth Johansson, Paulette Decottignies et al. · Journal of Biological Chemistry · 2000 · 27 citations · Full text

, , +17

1–5 of 5

Authors

22

  1. MT
    Masayuki Takahash

    The University of Osaka, Japan

    2 publications · 64 citations

    2

    h-index

  2. KM
    Katsumi Morimatsu

    The University of Osaka, Japan

    2 publications · 64 citations

    2

    h-index

  3. TH
    Toshihiro Horii

    The University of Osaka, Japan

    2 publications · 64 citations

    2

    h-index

  4. SF
    Shuya Fukai

    The University of Tokyo, Japan

    1 publications · 142 citations

    1

    h-index

  5. NS
    Nigel S. Scrutton

    University of Manchester, United Kingdom

    1 publications · 33 citations

    1

    h-index

1–5 of 22

Institutions

17

  1. Université Paris-Sud

    Orsay, France

    2 h-index

    4 publications

    111 citations

  2. Texas Tech University

    Lubbock, United States

    1 h-index

    4 publications

    108 citations

  3. Japan Science and Technology Agency

    Tokyo, Japan

    1 h-index

    1 publications

    142 citations

  4. Ehime University

    Matsuyama, Japan

    1 h-index

    4 publications

    568 citations

  5. AstraZeneca (Sweden)

    Södertälje, Sweden

    1 h-index

    1 publications

    33 citations

  6. Tokyo Institute of Technology

    Tokyo, Japan

    1 h-index

    2 publications

    284 citations

  7. Uppsala University

    Uppsala, Sweden

    1 h-index

    1 publications

    27 citations

  8. University of Manchester

    Manchester, United Kingdom

    1 h-index

    4 publications

    132 citations

1–8 of 17

Venues

  1. European Journal of Biochemistry

    EJB · 2 publications · 64 citations

    2

    h-index

  2. Structure

    1 publications · 142 citations

    1

    h-index

  3. Journal of Biological Chemistry

    JBC · 1 publications · 27 citations

    1

    h-index

  4. ACS Catalysis

    1 publications · 33 citations

    1

    h-index

1–4