Concepedia

Codon Optimization For Antigens

Codon Optimization for Antigens is a computational method in vaccine antigen design that involves adjusting the nucleotide sequence of an antigen-encoding gene to match the codon usage bias of the target expression system, thereby enhancing translational efficiency and antigen yield.

65

Publications

3K

Citations

387

Authors

138

Institutions

Publications per year

2017–2026

15

Parents

Publications

65

Optimization of Codon Usage of Plasmid DNA Vaccine Is Required for the Effective MHC Class I-Restricted T Cell Responses Against an Intracellular Bacterium

Masato Uchijima, Atsushi Yoshida, Toshi Nagata et al. · The Journal of Immunology · 1998 · 133 citations · Full text

, , +17

Effect of Codon Optimization on Expression Levels of a Functionally Folded Malaria Vaccine Candidate in Prokaryotic and Eukaryotic Expression Systems

Anjali Yadava, Christian F. Ockenhouse · Infection and Immunity · 2003 · 130 citations · Full text

, , +17

Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene

Lars Frelin, Gustaf Ahlén, Mats Alheim et al. · Gene Therapy · 2004 · 114 citations

, , +16

Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine

Shixia Wang, Diego J. Farfán-Arribas, Siyuan Shen et al. · Vaccine · 2005 · 103 citations

, , +17

Enhanced expression of a recombinant malaria candidate vaccine in Escherichia coli by codon optimization

Zhiyong Zhou, Paul Schnake, Lihua Xiao et al. · Protein Expression and Purification · 2004 · 101 citations

, , +17

1–5 of 65

Authors

387

  1. SW
    Shixia Wang

    University of Massachusetts Chan Medical School, United States

    4 publications · 305 citations

    4

    h-index

  2. SL
    Shan Lu

    University of Massachusetts Chan Medical School, United States

    4 publications · 305 citations

    4

    h-index

  3. TC
    Te-Hui Chou

    University of Massachusetts Chan Medical School, United States

    3 publications · 212 citations

    3

    h-index

  4. CD
    Christopher D. Johnston

    Fred Hutch Cancer Center, United States

    2 publications · 38 citations

    2

    h-index

  5. HC
    Hong Cao

    Chinese Academy of Sciences, China

    2 publications · 176 citations

    2

    h-index

1–5 of 387

Institutions

138

  1. University of Massachusetts Chan Medical School

    Worcester, United States

    4 h-index

    25 publications

    1.9K citations

  2. International Centre for Genetic Engineering and Biotechnology

    New Delhi, India

    2 h-index

    4 publications

    91 citations

  3. Munster Technological University

    Cork, Ireland

    2 h-index

    6 publications

    110 citations

  4. Chinese Academy of Agricultural Sciences

    Beijing, China

    2 h-index

    18 publications

    456 citations

  5. Center for Cancer Research

    Bethesda, United States

    2 h-index

    16 publications

    1.5K citations

  6. Central University of Rajasthan

    Ajmer, India

    2 h-index

    4 publications

    110 citations

  7. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    12 publications

    897 citations

  8. National Institutes of Health

    Bethesda, United States

    2 h-index

    17 publications

    1.6K citations

1–8 of 138

Venues

  1. Vaccine

    11 publications · 605 citations

    11

    h-index

  2. Journal of Virology

    JVI · 4 publications · 296 citations

    4

    h-index

  3. Protein Expression and Purification

    4 publications · 228 citations

    4

    h-index

  4. Scientific Reports

    3 publications · 117 citations

    3

    h-index

  5. Applied Microbiology and Biotechnology

    2 publications · 72 citations

    2

    h-index

1–5