Codon 13 Mutations is a specific type of oncogenic mutation in the RAS family of proto-oncogenes characterized by amino acid substitutions at the 13th codon position, predominantly involving glycine replacement, that impair GTPase activity and lead to constitutive activation of RAS signaling.
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A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior, Paul D. Lewis, Carla Mattos · Cancer Research · 2012 · 2.1K citations · Full text
Biological properties of human c-Ha-ras1 genes mutated at codon 12
Peter H. Seeburg, Wendy W. Colby, Daniel J. Capon et al. · Nature · 1984 · 587 citations
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