Concepedia

Cmg Helicase Complex

The CMG Helicase Complex is a eukaryotic DNA replication initiation complex that uniquely comprises the Cdc45-Mcm2-7-GINS proteins and functions as the active helicase responsible for unwinding double-stranded DNA at replication forks during S phase.

102

Publications

8.8K

Citations

392

Authors

149

Institutions

Publications per year

2017–2026

61

Variants

Cdc45-mcm-gins Complex

Parents

Publications

102

Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

Stephen E. Moyer, Peter W. Lewis, Michael R. Botchan · Proceedings of the National Academy of Sciences · 2006 · 698 citations · Full text

, , +14

Cellular and Molecular Life Sciences : CMLS

Magdalena M. Domon, Mehmet Nail Nasir, Gladys Matar et al. · 2011 · 624 citations

, , +10

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

Joseph T.P. Yeeles, Agnieska Janska, Anne Early et al. · Molecular Cell · 2016 · 380 citations · Full text

, , +17

The mechanism of eukaryotic CMG helicase activation

Max E. Douglas, Ferdos Abid Ali, Alessandro Costa et al. · Nature · 2018 · 288 citations · Full text

, , +6

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Marija Marić, Timurs Maculins, Giacomo De Piccoli et al. · Science · 2014 · 234 citations

, , +17

1–5 of 102

Authors

392

  1. AC
    Alessandro Costa

    The Francis Crick Institute, United Kingdom

    13 publications · 1.5K citations

    12

    h-index

  2. KL
    Karim Labib

    MRC Protein Phosphorylation and Ubiquitylation Unit, United Kingdom

    12 publications · 1K citations

    12

    h-index

  3. JF
    John F.X. Diffley

    The Francis Crick Institute, United Kingdom

    10 publications · 1.2K citations

    10

    h-index

  4. JT
    Joseph T.P. Yeeles

    MRC Laboratory of Molecular Biology, United Kingdom

    8 publications · 1.1K citations

    8

    h-index

  5. JC
    Johannes C. Walter

    Harvard University, United States

    7 publications · 692 citations

    7

    h-index

1–5 of 392

Institutions

149

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    40 publications

    4.3K citations

  2. The Francis Crick Institute

    London, United Kingdom

    14 h-index

    81 publications

    8.9K citations

  3. University of Dundee

    Dundee, United Kingdom

    12 h-index

    42 publications

    3.3K citations

  4. MRC Protein Phosphorylation and Ubiquitylation Unit

    Dundee, United Kingdom

    12 h-index

    40 publications

    2.9K citations

  5. Rockefeller University

    New York, United States

    11 h-index

    39 publications

    4K citations

  6. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    7 h-index

    29 publications

    2.9K citations

  7. Harvard University

    Cambridge, United States

    7 h-index

    25 publications

    2.7K citations

  8. University of Copenhagen

    Copenhagen, Denmark

    5 h-index

    15 publications

    1K citations

1–8 of 149

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 1.8K citations

    14

    h-index

  2. Nature Communications

    10 publications · 653 citations

    10

    h-index

  3. Molecular Cell

    8 publications · 1.1K citations

    8

    h-index

  4. Nucleic Acids Research

    6 publications · 252 citations

    6

    h-index

  5. Journal of Biological Chemistry

    JBC · 6 publications · 364 citations

    6

    h-index

1–5