Concepedia

Clock-bmal1 Heterodimer

CLOCK-BMAL1 Heterodimer is a transcriptional activator complex that belongs to the class of circadian regulatory proteins and is distinguished by the heterodimeric interaction between the CLOCK and BMAL1 basic helix-loop-helix PER-ARNT-SIM domain-containing transcription factors, which binds to E-box enhancer elements to drive the expression of core circadian clock genes.

290

Publications

32.7K

Citations

1.7K

Authors

503

Institutions

Publications per year

2017–2026

115

Variants

Clock-bmal1 Complex

Parents

Publications

290

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

Nicholas Gekakis, David Staknis, Hubert B. Nguyen et al. · Science · 1998 · 2K citations

, , +16

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Biliana Marcheva, Kathryn Moynihan Ramsey, Ethan D. Buhr et al. · Nature · 2010 · 1.5K citations · Full text

, , +12

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

Jared Rutter, Martin Reick, Leeju C. Wu et al. · Science · 2001 · 1.1K citations

, , +17

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors <i>per</i> and <i>tim</i>

Thomas K. Darlington, Karen Wager‐Smith, M. Fernanda Ceriani et al. · Science · 1998 · 826 citations

, , +16

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

Jürgen A. Ripperger, Ueli Schibler · Nature Genetics · 2006 · 593 citations

, , +14

1–5 of 290

Authors

1.7K

  1. JS
    Joseph S. Takahashi

    Howard Hughes Medical Institute, United States

    12 publications · 6K citations

    12

    h-index

  2. MP
    Marina P. Antoch

    Roswell Park Comprehensive Cancer Center, United States

    9 publications · 1.4K citations

    9

    h-index

  3. JB
    John B. Hogenesch

    University of Pennsylvania, United States

    9 publications · 1.3K citations

    9

    h-index

  4. KK
    Kyungjin Kim

    Seoul National University, South Korea

    8 publications · 893 citations

    8

    h-index

  5. CL
    Carrie L. Partch

    University of California, Santa Cruz, United States

    8 publications · 1.1K citations

    8

    h-index

1–5 of 1.7K

Institutions

503

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    42 publications

    29K citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    14 h-index

    38 publications

    13K citations

  3. University of Pennsylvania

    Philadelphia, United States

    11 h-index

    41 publications

    6.9K citations

  4. Seoul National University

    Seoul, South Korea

    9 h-index

    43 publications

    4.7K citations

  5. Harvard University

    Cambridge, United States

    9 h-index

    39 publications

    26.2K citations

  6. Kyoto University

    Kyoto, Japan

    8 h-index

    19 publications

    1.7K citations

  7. University of Manchester

    Manchester, United Kingdom

    8 h-index

    65 publications

    4.2K citations

  8. University of California, Santa Cruz

    Santa Cruz, United States

    8 h-index

    39 publications

    3.9K citations

1–8 of 503

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 3.4K citations

    19

    h-index

  2. Journal of Biological Chemistry

    JBC · 16 publications · 1.5K citations

    16

    h-index

  3. Science

    10 publications · 6.3K citations

    10

    h-index

  4. PLoS ONE

    10 publications · 643 citations

    10

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 10 publications · 600 citations

    10

    h-index

1–5