Concepedia

Chromosome-scale Engineering

Chromosome-Scale Engineering is a genome writing methodology that enables the design, synthesis, and precise modification of entire chromosomes or chromosomal segments, distinguishing it from smaller-scale genetic editing by its comprehensive, high-magnitude architectural control over eukaryotic genome structure and function.

7

Publications

3K

Citations

60

Authors

14

Institutions

Publications per year

2017–2026

4

Parents

Publications

7

Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions

Joshua N. Burton, Andrew Adey, Rupali P Patwardhan et al. · Nature Biotechnology · 2013 · 1.6K citations · Full text

, , +16

Automated assembly scaffolding using RagTag elevates a new tomato system for high-throughput genome editing

Michael Alonge, Ludivine Lebeigle, Melanie Kirsche et al. · Genome biology · 2022 · 942 citations · Full text

, , +13

The Genome Project-Write

Jef D. Boeke, George M. Church, Andrew Hessel et al. · Science · 2016 · 223 citations

, , +14

Automated assembly scaffolding elevates a new tomato system for high-throughput genome editing

Michael Alonge, Ludivine Lebeigle, Melanie Kirsche et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 106 citations · Full text

, , +15

Chromosome drives via CRISPR-Cas9 in yeast

Hui Xu, Mingzhe Han, Shiyi Zhou et al. · Nature Communications · 2020 · 40 citations · Full text

, , +17

1–5 of 7

Authors

60

  1. MK
    Melanie Kirsche

    Johns Hopkins University, United States

    2 publications · 1K citations

    2

    h-index

  2. LL
    Ludivine Lebeigle

    University of Lausanne, Switzerland

    2 publications · 1K citations

    2

    h-index

  3. XW
    Xingang Wang

    Chinese Academy of Sciences, China

    2 publications · 1K citations

    2

    h-index

  4. ZB
    Zachary B. Lippman

    Cold Spring Harbor Laboratory, United States

    2 publications · 1K citations

    2

    h-index

  5. MA
    Michael Alonge

    Johns Hopkins University, United States

    2 publications · 1K citations

    2

    h-index

1–5 of 60

Institutions

14

  1. University of Lausanne

    Lausanne, Switzerland

    2 h-index

    4 publications

    2.1K citations

  2. Johns Hopkins University

    Baltimore, United States

    2 h-index

    10 publications

    6.1K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    1K citations

  4. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    2 h-index

    6 publications

    3.1K citations

  5. Sab Biotherapeutics (United States)

    Sioux Falls, United States

    1 h-index

    4 publications

    152 citations

  6. Kyowa Kirin (Japan)

    Tokyo, Japan

    1 h-index

    2 publications

    76 citations

  7. Utah State University

    Logan, United States

    1 h-index

    1 publications

    38 citations

  8. Anstalt für Verbrennungskraftmaschinen List (Austria)

    Graz, Austria

    1 h-index

    25 publications

    5.6K citations

1–8 of 14

Venues

  1. Genome biology

    1 publications · 942 citations

    1

    h-index

  2. Science

    1 publications · 223 citations

    1

    h-index

  3. Nature Communications

    1 publications · 40 citations

    1

    h-index

  4. Nature Biotechnology

    1 publications · 1.6K citations

    1

    h-index

  5. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 1 publications · 106 citations

    1

    h-index

1–5